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Mendeley readers
Attention Score in Context
| Title |
Human Microglial Cells Synthesize Albumin in Brain
|
|---|---|
| Published in |
PLOS ONE, July 2008
|
| DOI | 10.1371/journal.pone.0002829 |
| Pubmed ID | |
| Authors |
Sung-Min Ahn, Kyunghee Byun, Kun Cho, Jin Young Kim, Jong Shin Yoo, Deokhoon Kim, Sun Ha Paek, Seung U. Kim, Richard J. Simpson, Bonghee Lee |
| Abstract |
Albumin, an abundant plasma protein with multifunctional properties, is mainly synthesized in the liver. Albumin has been implicated in Alzheimer's disease (AD) since it can bind to and transport amyloid beta (Abeta), the causative agent of AD; albumin is also a potent inhibitor of Abeta polymerization. Despite evidence of non-hepatic transcription of albumin in many tissues including kidney and pancreas, non-hepatic synthesis of albumin at the protein level has been rarely confirmed. In a pilot phase study of Human Brain Proteome Project, we found evidence that microglial cells in brain may synthesize albumin. Here we report, for the first time, the de novo synthesis of albumin in human microglial cells in brain. Furthermore, we demonstrate that the synthesis and secretion of albumin from microglial cells is enhanced upon microglial activation by Abeta(1-42)- or lipopolysaccharide (LPS)-treatment. These data indicate that microglial cells may play a beneficial role in AD by secreting albumin that not only inhibits Abeta polymerization but also increases its clearance. |
Mendeley readers
The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 2 | 1% |
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 145 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 27 | 18% |
| Researcher | 24 | 16% |
| Student > Master | 16 | 11% |
| Student > Bachelor | 13 | 9% |
| Student > Doctoral Student | 12 | 8% |
| Other | 28 | 19% |
| Unknown | 30 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 23% |
| Medicine and Dentistry | 22 | 15% |
| Biochemistry, Genetics and Molecular Biology | 19 | 13% |
| Neuroscience | 15 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 20 | 13% |
| Unknown | 34 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2017.
All research outputs
#6,377,613
of 22,660,862 outputs
Outputs from PLOS ONE
#76,338
of 193,497 outputs
Outputs of similar age
#25,355
of 81,693 outputs
Outputs of similar age from PLOS ONE
#279
of 461 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 193,497 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,693 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 461 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.