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Mendeley readers
Attention Score in Context
| Title |
Production of p53 gene knockout rats by homologous recombination in embryonic stem cells
|
|---|---|
| Published in |
Nature, August 2010
|
| DOI | 10.1038/nature09368 |
| Pubmed ID | |
| Authors |
Chang Tong, Ping Li, Nancy L. Wu, Youzhen Yan, Qi-Long Ying |
| Abstract |
The use of homologous recombination to modify genes in embryonic stem (ES) cells provides a powerful means to elucidate gene function and create disease models. Application of this technology to engineer genes in rats has not previously been possible because of the absence of germline-competent ES cells in this species. We have recently established authentic rat ES cells. Here we report the generation of gene knockout rats using the ES-cell-based gene targeting technology. We designed a targeting vector to disrupt the tumour suppressor gene p53 (also known as Tp53) in rat ES cells by means of homologous recombination. p53 gene-targeted rat ES cells can be routinely generated. Furthermore, the p53 gene-targeted mutation in the rat ES-cell genome can transmit through the germ line via ES-cell rat chimaeras to create p53 gene knockout rats. The rat is the most widely used animal model in biological research. The establishment of gene targeting technology in rat ES cells, in combination with advances in genomics and the vast amount of research data on physiology and pharmacology in this species, now provide a powerful new platform for the study of human disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 300 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 2% |
| Japan | 3 | 1% |
| France | 3 | 1% |
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| Sweden | 1 | <1% |
| South Africa | 1 | <1% |
| Chile | 1 | <1% |
| Brazil | 1 | <1% |
| Other | 7 | 2% |
| Unknown | 272 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 87 | 29% |
| Student > Ph. D. Student | 63 | 21% |
| Student > Master | 24 | 8% |
| Student > Bachelor | 24 | 8% |
| Professor > Associate Professor | 23 | 8% |
| Other | 55 | 18% |
| Unknown | 24 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 180 | 60% |
| Biochemistry, Genetics and Molecular Biology | 35 | 12% |
| Medicine and Dentistry | 33 | 11% |
| Neuroscience | 7 | 2% |
| Immunology and Microbiology | 4 | 1% |
| Other | 15 | 5% |
| Unknown | 26 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 March 2024.
All research outputs
#2,462,348
of 23,572,442 outputs
Outputs from Nature
#44,833
of 92,652 outputs
Outputs of similar age
#9,255
of 96,170 outputs
Outputs of similar age from Nature
#278
of 592 outputs
Altmetric has tracked 23,572,442 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 92,652 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 100.5. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 96,170 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 592 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 53% of its contemporaries.