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Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2

Overview of attention for article published in PLOS ONE, October 2009
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Title
Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2
Published in
PLOS ONE, October 2009
DOI 10.1371/journal.pone.0007411
Pubmed ID
Authors

Maximiliano J. Jimenez-Dalmaroni, Nengming Xiao, Adam L. Corper, Petra Verdino, Gary D. Ainge, Dave S. Larsen, Gavin F. Painter, Pauline M. Rudd, Raymond A. Dwek, Kasper Hoebe, Bruce Beutler, Ian A. Wilson

Abstract

Cluster of differentiation 36 (CD36) is a transmembrane glycoprotein involved in many biological processes, such as platelet biology, angiogenesis and in the aetiopathology of atherosclerosis and cardiovascular diseases. Toll-like receptors (TLRs) are one of the most important receptors of the innate immune system. Their main function is the recognition of conserved structure of microorganisms. This recognition triggers signaling pathways that activate transcription of cytokines and co-stimulatory molecules which participate in the generation of an immune response against microbes. In particular, TLR2 has been shown to recognize a broad range of ligands. Recently, we showed that CD36 serves as a co-receptor for TLR2 and enhances recognition of specific diacylglycerides derived from bacteria.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 1%
Netherlands 1 1%
United Kingdom 1 1%
Denmark 1 1%
Japan 1 1%
Unknown 94 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 23 23%
Researcher 21 21%
Student > Master 12 12%
Professor > Associate Professor 7 7%
Student > Bachelor 6 6%
Other 16 16%
Unknown 14 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 42 42%
Medicine and Dentistry 12 12%
Biochemistry, Genetics and Molecular Biology 10 10%
Immunology and Microbiology 8 8%
Chemistry 3 3%
Other 8 8%
Unknown 16 16%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 November 2009.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from PLOS ONE
#129,767
of 193,497 outputs
Outputs of similar age
#78,034
of 93,676 outputs
Outputs of similar age from PLOS ONE
#458
of 547 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,497 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,676 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 547 others from the same source and published within six weeks on either side of this one. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.