You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway
|
|---|---|
| Published in |
PLOS ONE, July 2009
|
| DOI | 10.1371/journal.pone.0006189 |
| Pubmed ID | |
| Authors |
Hui H. Zhang, Jingxiang Huang, Katrin Düvel, Bernard Boback, Shulin Wu, Rachel M. Squillace, Chin-Lee Wu, Brendan D. Manning |
| Abstract |
The signaling pathways imposing hormonal control over adipocyte differentiation are poorly understood. While insulin and Akt signaling have been found previously to be essential for adipogenesis, the relative importance of their many downstream branches have not been defined. One direct substrate that is inhibited by Akt-mediated phosphorylation is the tuberous sclerosis complex 2 (TSC2) protein, which associates with TSC1 and acts as a critical negative regulator of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1). Loss of function of the TSC1-TSC2 complex results in constitutive mTORC1 signaling and, through mTORC1-dependent feedback mechanisms and loss of mTORC2 activity, leads to a concomitant block of Akt signaling to its other downstream targets. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 33% |
| United States | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 291 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 1% |
| Germany | 2 | <1% |
| United Kingdom | 2 | <1% |
| Netherlands | 1 | <1% |
| Chile | 1 | <1% |
| Austria | 1 | <1% |
| Japan | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 279 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 72 | 25% |
| Researcher | 52 | 18% |
| Student > Master | 31 | 11% |
| Student > Bachelor | 23 | 8% |
| Student > Doctoral Student | 17 | 6% |
| Other | 46 | 16% |
| Unknown | 50 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 109 | 37% |
| Biochemistry, Genetics and Molecular Biology | 72 | 25% |
| Medicine and Dentistry | 27 | 9% |
| Neuroscience | 6 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 2% |
| Other | 18 | 6% |
| Unknown | 53 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2020.
All research outputs
#6,531,102
of 25,483,400 outputs
Outputs from PLOS ONE
#93,498
of 222,090 outputs
Outputs of similar age
#34,357
of 122,856 outputs
Outputs of similar age from PLOS ONE
#211
of 505 outputs
Altmetric has tracked 25,483,400 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 222,090 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 122,856 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 505 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.