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Mendeley readers
Attention Score in Context
| Title |
Maternal Obesity Induced by Diet in Rats Permanently Influences Central Processes Regulating Food Intake in Offspring
|
|---|---|
| Published in |
PLOS ONE, June 2009
|
| DOI | 10.1371/journal.pone.0005870 |
| Pubmed ID | |
| Authors |
Shona L. Kirk, Anne-Maj Samuelsson, Marco Argenton, Hannah Dhonye, Theodosis Kalamatianos, Lucilla Poston, Paul D. Taylor, Clive W. Coen |
| Abstract |
Hypothalamic systems which regulate appetite may be permanently modified during early development. We have previously reported hyperphagia and increased adiposity in the adult offspring of rodents fed an obesogenic diet prior to and throughout pregnancy and lactation. We now report that offspring of obese (OffOb) rats display an amplified and prolonged neonatal leptin surge, which is accompanied by elevated leptin mRNA expression in their abdominal white adipose tissue. At postnatal Day 30, before the onset of hyperphagia in these animals, serum leptin is normal, but leptin-induced appetite suppression and phosphorylation of STAT3 in the arcuate nucleus (ARC) are attenuated; the level of AgRP-immunoreactivity in the hypothalamic paraventricular nucleus (PVH), which derives from neurones in the ARC and is developmentally dependent on leptin, is also diminished. We hypothesise that prolonged release of abnormally high levels of leptin by neonatal OffOb rats leads to leptin resistance and permanently affects hypothalamic functions involving the ARC and PVH. Such effects may underlie the developmental programming of hyperphagia and obesity in these rats. |
Mendeley readers
The data shown below were compiled from readership statistics for 215 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 211 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 42 | 20% |
| Student > Bachelor | 41 | 19% |
| Student > Master | 27 | 13% |
| Student > Doctoral Student | 16 | 7% |
| Researcher | 14 | 7% |
| Other | 43 | 20% |
| Unknown | 32 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 62 | 29% |
| Medicine and Dentistry | 33 | 15% |
| Biochemistry, Genetics and Molecular Biology | 31 | 14% |
| Neuroscience | 26 | 12% |
| Psychology | 6 | 3% |
| Other | 16 | 7% |
| Unknown | 41 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 July 2009.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from PLOS ONE
#129,767
of 193,497 outputs
Outputs of similar age
#95,602
of 112,365 outputs
Outputs of similar age from PLOS ONE
#425
of 505 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,497 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 112,365 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 505 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.