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Intense Synaptic Activity Enhances Temporal Resolution in Spinal Motoneurons

Overview of attention for article published in PLOS ONE, September 2008
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Title
Intense Synaptic Activity Enhances Temporal Resolution in Spinal Motoneurons
Published in
PLOS ONE, September 2008
DOI 10.1371/journal.pone.0003218
Pubmed ID
Authors

Rune W. Berg, Susanne Ditlevsen, Jørn Hounsgaard

Abstract

In neurons, spike timing is determined by integration of synaptic potentials in delicate concert with intrinsic properties. Although the integration time is functionally crucial, it remains elusive during network activity. While mechanisms of rapid processing are well documented in sensory systems, agility in motor systems has received little attention. Here we analyze how intense synaptic activity affects integration time in spinal motoneurons during functional motor activity and report a 10-fold decrease. As a result, action potentials can only be predicted from the membrane potential within 10 ms of their occurrence and detected for less than 10 ms after their occurrence. Being shorter than the average inter-spike interval, the AHP has little effect on integration time and spike timing, which instead is entirely determined by fluctuations in membrane potential caused by the barrage of inhibitory and excitatory synaptic activity. By shortening the effective integration time, this intense synaptic input may serve to facilitate the generation of rapid changes in movements.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Japan 1 2%
Argentina 1 2%
Canada 1 2%
Unknown 48 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 23%
Researcher 12 23%
Professor 6 12%
Professor > Associate Professor 5 10%
Student > Master 5 10%
Other 6 12%
Unknown 6 12%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 35%
Neuroscience 11 21%
Medicine and Dentistry 7 13%
Engineering 2 4%
Psychology 2 4%
Other 8 15%
Unknown 4 8%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 March 2009.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from PLOS ONE
#129,767
of 193,497 outputs
Outputs of similar age
#63,215
of 74,472 outputs
Outputs of similar age from PLOS ONE
#393
of 451 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,497 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 74,472 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 451 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.