Title |
Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis
|
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Published in |
BMC Genomics, July 2008
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DOI | 10.1186/1471-2164-9-340 |
Pubmed ID | |
Authors |
Marcel Scheideler, Christian Elabd, Laure-Emmanuelle Zaragosi, Chiara Chiellini, Hubert Hackl, Fatima Sanchez-Cabo, Sunaina Yadav, Kalina Duszka, Gerald Friedl, Christine Papak, Andreas Prokesch, Reinhard Windhager, Gerard Ailhaud, Christian Dani, Ez-Zoubir Amri, Zlatko Trajanoski |
Abstract |
A reciprocal relationship between bone and fat development in osteoporosis is clinically well established. Some of the key molecular regulators involved in this tissue replacement process have been identified. The detailed mechanisms governing the differentiation of mesenchymal stem cells (MSC) - the key cells involved - are however only now beginning to emerge. In an attempt to address the regulation of the adipocyte/osteoblast balance at the level of gene transcription in a comprehensive and unbiased manner, we performed a large-scale gene expression profiling study using a unique cellular model, human multipotent adipose tissue-derived stem cells (hMADS). |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 2% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Denmark | 1 | <1% |
Iceland | 1 | <1% |
Spain | 1 | <1% |
Luxembourg | 1 | <1% |
Unknown | 121 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 34 | 26% |
Student > Ph. D. Student | 30 | 23% |
Professor > Associate Professor | 11 | 9% |
Student > Master | 10 | 8% |
Professor | 8 | 6% |
Other | 20 | 16% |
Unknown | 16 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 63 | 49% |
Biochemistry, Genetics and Molecular Biology | 21 | 16% |
Medicine and Dentistry | 15 | 12% |
Chemistry | 2 | 2% |
Business, Management and Accounting | 1 | <1% |
Other | 6 | 5% |
Unknown | 21 | 16% |