Title |
Exacerbation of allergic inflammation in mice exposed to diesel exhaust particles prior to viral infection
|
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Published in |
Particle and Fibre Toxicology, August 2009
|
DOI | 10.1186/1743-8977-6-22 |
Pubmed ID | |
Authors |
Ilona Jaspers, Patricia A Sheridan, Wenli Zhang, Luisa E Brighton, Kelly D Chason, Xiaoyang Hua, Stephen L Tilley |
Abstract |
Viral infections and exposure to oxidant air pollutants are two of the most important inducers of asthma exacerbation. Our previous studies have demonstrated that exposure to diesel exhaust increases the susceptibility to influenza virus infections both in epithelial cells in vitro and in mice in vivo. Therefore, we examined whether in the setting of allergic asthma, exposure to oxidant air pollutants enhances the susceptibility to respiratory virus infections, which in turn leads to increased virus-induced exacerbation of asthma. Ovalbumin-sensitized (OVA) male C57BL/6 mice were instilled with diesel exhaust particles (DEP) or saline and 24 hours later infected with influenza A/PR/8. Animals were sacrificed 24 hours post-infection and analyzed for markers of lung injury, allergic inflammation, and pro-inflammatory cytokine production. |
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