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Mendeley readers
Attention Score in Context
| Title |
Differential Phagocytosis of White versus Opaque Candida albicans by Drosophila and Mouse Phagocytes
|
|---|---|
| Published in |
PLOS ONE, January 2008
|
| DOI | 10.1371/journal.pone.0001473 |
| Pubmed ID | |
| Authors |
Matthew B. Lohse, Alexander D. Johnson |
| Abstract |
The human fungal pathogen Candida albicans resides asymptomatically in the gut of most healthy people but causes serious invasive diseases in immunocompromised patients. Many C. albicans strains have the ability to stochastically switch between distinct white and opaque cell types, but it is not known with certainty what role this switching plays in the physiology of the organism. Here, we report a previously undescribed difference between white and opaque cells, namely their interaction with host phagocytic cells. We show that both Drosophila hemocyte-derived S2 cells and mouse macrophage-derived RAW264.7 cells preferentially phagocytose white cells over opaque cells. This difference is seen both in the overall percentage of cultured cells that phagocytose white versus opaque C. albicans and in the average number of C. albicans taken up by each phagocytic cell. We conclude that susceptibility to phagocytosis by cells of the innate immune system is an important distinction between white and opaque C. albicans, and propose that one role of switching from the prevalent white form into the rarer opaque form may be to allow C. albicans to escape phagocytosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 85 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 4% |
| Ireland | 1 | 1% |
| Egypt | 1 | 1% |
| Unknown | 80 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 23 | 27% |
| Researcher | 19 | 22% |
| Student > Bachelor | 6 | 7% |
| Student > Master | 6 | 7% |
| Student > Doctoral Student | 5 | 6% |
| Other | 11 | 13% |
| Unknown | 15 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 44% |
| Biochemistry, Genetics and Molecular Biology | 17 | 20% |
| Immunology and Microbiology | 8 | 9% |
| Medicine and Dentistry | 3 | 4% |
| Unspecified | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 16 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 January 2008.
All research outputs
#15,240,835
of 22,660,862 outputs
Outputs from PLOS ONE
#129,767
of 193,497 outputs
Outputs of similar age
#129,962
of 155,052 outputs
Outputs of similar age from PLOS ONE
#213
of 240 outputs
Altmetric has tracked 22,660,862 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 193,497 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 155,052 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 240 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.