Chapter title |
Chemotherapy-Induced Takotsubo Syndrome
|
---|---|
Chapter number | 222 |
Book title |
Clinical Pulmonary Research
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/5584_2018_222 |
Pubmed ID | |
Book ISBNs |
978-3-03-003869-4, 978-3-03-003870-0
|
Authors |
Monika Budnik, Jakub Kucharz, Paweł Wiechno, Tomasz Demkow, Janusz Kochanowski, Elżbieta Górska, Grzegorz Opolski, Budnik, Monika, Kucharz, Jakub, Wiechno, Paweł, Demkow, Tomasz, Kochanowski, Janusz, Górska, Elżbieta, Opolski, Grzegorz |
Abstract |
Cardiovascular complications are a significant problem in systemically treated cancer patients. One such complication is Takotsubo cardiomyopathy, also known as Takotsubo syndrome. It is most frequently defined as a sudden and transient left or right ventricular systolic dysfunction; mimicking acute coronary syndrome, but without the associated changes in coronary arteries. Takotsubo syndrome is a relatively little known complication that appears in the course of oncological treatment, and its incidence has not yet been established. In this study, we reviewed Medline database according to case reports concerning takotsubo syndrome appearing after systemic treatment in oncological patients. We took into consideration all types of anticancer drugs. We reviewed the changes reported in the electrocardiography, echocardiography, and coronary angiography, and also the level of troponin, a marker of acute coronary syndrome elevation. In view of the increasing frequency of cardiac complications reported in patients receiving systemic oncological treatment, Takotsubo syndrome appears to be underdiagnosed. However, the syndrome may be linked to potentially fatal complications such as cardiogenic shock or cardiac arrest. Therefore, it seems essential to carry out appropriate diagnostic procedures for every patient experiencing clinical side effects of onco-pharmacotherapy. In patients with chest pain and dyspnea during or after treatment, Takotsubo syndrome should be considered, particularly that the syndrome requires a different therapy approach than that used in a coronary syndrome. Diagnostic procedures should include echocardiogram and the assessment of myocardial necrosis markers and natriuretic peptides. |
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United Kingdom | 2 | 100% |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 26 | 100% |
Demographic breakdown
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Student > Doctoral Student | 4 | 15% |
Student > Bachelor | 4 | 15% |
Librarian | 2 | 8% |
Student > Master | 2 | 8% |
Student > Ph. D. Student | 1 | 4% |
Other | 2 | 8% |
Unknown | 11 | 42% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 6 | 23% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 4% |
Psychology | 1 | 4% |
Engineering | 1 | 4% |
Other | 0 | 0% |
Unknown | 15 | 58% |