You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Molecular Dynamics Simulations Suggest that Electrostatic Funnel Directs Binding of Tamiflu to Influenza N1 Neuraminidases
|
|---|---|
| Published in |
PLoS Computational Biology, September 2010
|
| DOI | 10.1371/journal.pcbi.1000939 |
| Pubmed ID | |
| Authors |
Ly Le, Eric H. Lee, David J. Hardy, Thanh N. Truong, Klaus Schulten |
| Abstract |
Oseltamivir (Tamiflu) is currently the frontline antiviral drug employed to fight the flu virus in infected individuals by inhibiting neuraminidase, a flu protein responsible for the release of newly synthesized virions. However, oseltamivir resistance has become a critical problem due to rapid mutation of the flu virus. Unfortunately, how mutations actually confer drug resistance is not well understood. In this study, we employ molecular dynamics (MD) and steered molecular dynamics (SMD) simulations, as well as graphics processing unit (GPU)-accelerated electrostatic mapping, to uncover the mechanism behind point mutation induced oseltamivir-resistance in both H5N1 "avian" and H1N1pdm "swine" flu N1-subtype neuraminidases. The simulations reveal an electrostatic binding funnel that plays a key role in directing oseltamivir into and out of its binding site on N1 neuraminidase. The binding pathway for oseltamivir suggests how mutations disrupt drug binding and how new drugs may circumvent the resistance mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 101 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 7% |
| Indonesia | 2 | 2% |
| Denmark | 2 | 2% |
| France | 1 | <1% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Russia | 1 | <1% |
| China | 1 | <1% |
| Unknown | 85 | 84% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 27 | 27% |
| Student > Ph. D. Student | 19 | 19% |
| Student > Master | 14 | 14% |
| Professor | 6 | 6% |
| Student > Postgraduate | 6 | 6% |
| Other | 20 | 20% |
| Unknown | 9 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 36 | 36% |
| Chemistry | 22 | 22% |
| Biochemistry, Genetics and Molecular Biology | 13 | 13% |
| Physics and Astronomy | 5 | 5% |
| Computer Science | 4 | 4% |
| Other | 10 | 10% |
| Unknown | 11 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 March 2020.
All research outputs
#3,828,236
of 25,628,260 outputs
Outputs from PLoS Computational Biology
#3,294
of 9,018 outputs
Outputs of similar age
#15,062
of 106,818 outputs
Outputs of similar age from PLoS Computational Biology
#15
of 58 outputs
Altmetric has tracked 25,628,260 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,018 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 106,818 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.