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Mendeley readers
Attention Score in Context
| Title |
Mechanism of shape determination in motile cells
|
|---|---|
| Published in |
Nature, May 2008
|
| DOI | 10.1038/nature06952 |
| Pubmed ID | |
| Authors |
Kinneret Keren, Zachary Pincus, Greg M. Allen, Erin L. Barnhart, Gerard Marriott, Alex Mogilner, Julie A. Theriot |
| Abstract |
The shape of motile cells is determined by many dynamic processes spanning several orders of magnitude in space and time, from local polymerization of actin monomers at subsecond timescales to global, cell-scale geometry that may persist for hours. Understanding the mechanism of shape determination in cells has proved to be extremely challenging due to the numerous components involved and the complexity of their interactions. Here we harness the natural phenotypic variability in a large population of motile epithelial keratocytes from fish (Hypsophrys nicaraguensis) to reveal mechanisms of shape determination. We find that the cells inhabit a low-dimensional, highly correlated spectrum of possible functional states. We further show that a model of actin network treadmilling in an inextensible membrane bag can quantitatively recapitulate this spectrum and predict both cell shape and speed. Our model provides a simple biochemical and biophysical basis for the observed morphology and behaviour of motile cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 846 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 20 | 2% |
| Germany | 6 | <1% |
| France | 6 | <1% |
| United Kingdom | 6 | <1% |
| Japan | 5 | <1% |
| Czechia | 2 | <1% |
| Switzerland | 2 | <1% |
| Portugal | 2 | <1% |
| Singapore | 2 | <1% |
| Other | 12 | 1% |
| Unknown | 783 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 250 | 30% |
| Researcher | 203 | 24% |
| Student > Master | 63 | 7% |
| Professor > Associate Professor | 61 | 7% |
| Student > Bachelor | 47 | 6% |
| Other | 142 | 17% |
| Unknown | 80 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 289 | 34% |
| Physics and Astronomy | 134 | 16% |
| Biochemistry, Genetics and Molecular Biology | 116 | 14% |
| Engineering | 80 | 9% |
| Medicine and Dentistry | 25 | 3% |
| Other | 109 | 13% |
| Unknown | 93 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 17. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 June 2023.
All research outputs
#2,034,102
of 24,032,151 outputs
Outputs from Nature
#42,069
of 93,977 outputs
Outputs of similar age
#4,945
of 81,385 outputs
Outputs of similar age from Nature
#159
of 566 outputs
Altmetric has tracked 24,032,151 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 93,977 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 101.3. This one has gotten more attention than average, scoring higher than 55% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 81,385 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 566 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.