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AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Overview of attention for article published in Nature, January 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

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8 patents
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1 Wikipedia page
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1 research highlight platform

Citations

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1079 Dimensions

Readers on

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565 Mendeley
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2 Connotea
Title
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
Published in
Nature, January 2009
DOI 10.1038/nature07710
Pubmed ID
Authors

Teresa Fernandes-Alnemri, Je-Wook Yu, Pinaki Datta, Jianghong Wu, Emad S. Alnemri

Abstract

Host- and pathogen-associated cytoplasmic double-stranded DNA triggers the activation of a NALP3 (also known as cryopyrin and NLRP3)-independent inflammasome, which activates caspase-1 leading to maturation of pro-interleukin-1beta and inflammation. The nature of the cytoplasmic-DNA-sensing inflammasome is currently unknown. Here we show that AIM2 (absent in melanoma 2), an interferon-inducible HIN-200 family member that contains an amino-terminal pyrin domain and a carboxy-terminal oligonucleotide/oligosaccharide-binding domain, senses cytoplasmic DNA by means of its oligonucleotide/oligosaccharide-binding domain and interacts with ASC (apoptosis-associated speck-like protein containing a CARD) through its pyrin domain to activate caspase-1. The interaction of AIM2 with ASC also leads to the formation of the ASC pyroptosome, which induces pyroptotic cell death in cells containing caspase-1. Knockdown of AIM2 by short interfering RNA reduced inflammasome/pyroptosome activation by cytoplasmic DNA in human and mouse macrophages, whereas stable expression of AIM2 in the non-responsive human embryonic kidney 293T cell line conferred responsiveness to cytoplasmic DNA. Our results show that cytoplasmic DNA triggers formation of the AIM2 inflammasome by inducing AIM2 oligomerization. This study identifies AIM2 as an important inflammasome component that senses potentially dangerous cytoplasmic DNA, leading to activation of the ASC pyroptosome and caspase-1.

Mendeley readers

The data shown below were compiled from readership statistics for 565 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 15 3%
Germany 6 1%
France 6 1%
United Kingdom 3 <1%
Turkey 2 <1%
Netherlands 2 <1%
Australia 2 <1%
South Africa 1 <1%
Switzerland 1 <1%
Other 10 2%
Unknown 517 92%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 160 28%
Researcher 120 21%
Student > Master 72 13%
Student > Bachelor 53 9%
Professor > Associate Professor 33 6%
Other 95 17%
Unknown 32 6%
Readers by discipline Count As %
Agricultural and Biological Sciences 266 47%
Immunology and Microbiology 85 15%
Biochemistry, Genetics and Molecular Biology 76 13%
Medicine and Dentistry 58 10%
Neuroscience 10 2%
Other 23 4%
Unknown 47 8%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 August 2019.
All research outputs
#1,746,656
of 14,843,716 outputs
Outputs from Nature
#36,421
of 73,275 outputs
Outputs of similar age
#21,873
of 214,836 outputs
Outputs of similar age from Nature
#710
of 1,050 outputs
Altmetric has tracked 14,843,716 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 73,275 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 82.2. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 214,836 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1,050 others from the same source and published within six weeks on either side of this one. This one is in the 32nd percentile – i.e., 32% of its contemporaries scored the same or lower than it.