Chapter title |
Design of Microbubbles for Gene/Drug Delivery.
|
---|---|
Chapter number | 11 |
Book title |
Therapeutic Ultrasound
|
Published in |
Advances in experimental medicine and biology, January 2016
|
DOI | 10.1007/978-3-319-22536-4_11 |
Pubmed ID | |
Book ISBNs |
978-3-31-922535-7, 978-3-31-922536-4
|
Authors |
Thierry Bettinger, François Tranquart |
Editors |
Jean-Michel Escoffre, Ayache Bouakaz |
Abstract |
The role of ultrasound contrast agents (UCA) initially designed for diagnosis has evolved towards a therapeutic use. Ultrasound (US) for triggered drug delivery has many advantages. In particular, it enables a high spatial control of drug release, thus potentially allowing activation of drug delivery only in the targeted region, and not in surrounding healthy tissue. Moreover, UCA imaging can also be used firstly to precisely locate the target region to, and then used to monitor the drug delivery process by tracking the location of release occurrence. All these features make UCA and ultrasound attractive means to mediate drug delivery. The three main potential clinical indications for drug/gene US delivery are (i) the cardiovascular system, (ii) the central nervous system for small molecule delivery, and (iii) tumor therapy using cytotoxic drugs. Although promising results have been achieved in preclinical studies in various animal models, still very few examples of clinical use have been reported. In this chapter will be addressed the aspects pertaining to UCA formulation (chemical composition, mode of preparation, analytical methods…) and the requirement for a potential translation into the clinic following approval by regulatory authorities. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 19% |
Researcher | 4 | 19% |
Student > Ph. D. Student | 4 | 19% |
Student > Doctoral Student | 2 | 10% |
Student > Bachelor | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Engineering | 4 | 19% |
Medicine and Dentistry | 3 | 14% |
Biochemistry, Genetics and Molecular Biology | 2 | 10% |
Physics and Astronomy | 2 | 10% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
Other | 2 | 10% |
Unknown | 7 | 33% |