| Chapter title |
The Role of the Gadd45 Family in the Nervous System: A Focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics.
|
|---|---|
| Chapter number | 6 |
| Book title |
Gadd45 Stress Sensor Genes
|
| Published in |
Advances in experimental medicine and biology, January 2013
|
| DOI | 10.1007/978-1-4614-8289-5_6 |
| Pubmed ID | |
| Book ISBNs |
978-1-4614-8288-8, 978-1-4614-8289-5
|
| Authors |
Faraz A Sultan, J David Sweatt, Faraz A. Sultan, J. David Sweatt, Sultan, Faraz A., Sweatt, J. David |
| Abstract |
The growth arrest and DNA damage-inducible (Gadd)45 proteins have been associated with numerous cellular mechanisms including cell-cycle control, DNA damage sensation and repair, genotoxic stress, neoplasia, and molecular epigenetics. The genes were originally identified in in vitro screens of irradiation- and interleukin-induced transcription and have since been implicated in a host of normal and aberrant central nervous system processes. These include early and postnatal development, injury, cancer, memory, aging, and neurodegenerative and psychiatric disease states. The proteins act through a variety of molecular signaling cascades including the MAPK cascade, cell-cycle control mechanisms, histone regulation, and epigenetic DNA demethylation. In this review, we provide a comprehensive discussion of the literature implicating each of the three members of the Gadd45 family in these processes. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 44 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 20% |
| Researcher | 5 | 11% |
| Other | 3 | 7% |
| Professor > Associate Professor | 3 | 7% |
| Student > Master | 3 | 7% |
| Other | 9 | 20% |
| Unknown | 13 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 22% |
| Agricultural and Biological Sciences | 5 | 11% |
| Psychology | 5 | 11% |
| Medicine and Dentistry | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Other | 4 | 9% |
| Unknown | 14 | 31% |