The data shown below were compiled from readership statistics for 285 Mendeley readers of this research output. Click here to see the associated Mendeley record.
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Mendeley readers
Attention Score in Context
| Title |
Rab-coupling protein coordinates recycling of α5β1 integrin and EGFR1 to promote cell migration in 3D microenvironments
|
|---|---|
| Published in |
Journal of Cell Biology, October 2008
|
| DOI | 10.1083/jcb.200804140 |
| Pubmed ID | |
| Authors |
Patrick T. Caswell, May Chan, Andrew J. Lindsay, Mary W. McCaffrey, David Boettiger, Jim C. Norman |
| Abstract |
Here we show that blocking the adhesive function of alphavbeta3 integrin with soluble RGD ligands, such as osteopontin or cilengitide, promoted association of Rab-coupling protein (RCP) with alpha5beta1 integrin and drove RCP-dependent recycling of alpha5beta1 to the plasma membrane and its mobilization to dynamic ruffling protrusions at the cell front. These RCP-driven changes in alpha5beta1 trafficking led to acquisition of rapid/random movement on two-dimensional substrates and to a marked increase in fibronectin-dependent migration of tumor cells into three-dimensional matrices. Recycling of alpha5beta1 integrin did not affect its regulation or ability to form adhesive bonds with substrate fibronectin. Instead, alpha5beta1 controlled the association of EGFR1 with RCP to promote the coordinate recycling of these two receptors. This modified signaling downstream of EGFR1 to increase its autophosphorylation and activation of the proinvasive kinase PKB/Akt. We conclude that RCP provides a scaffold that promotes the physical association and coordinate trafficking of alpha5beta1 and EGFR1 and that this drives migration of tumor cells into three-dimensional matrices. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 4 | 1% |
| Germany | 3 | 1% |
| France | 2 | <1% |
| Spain | 2 | <1% |
| United States | 2 | <1% |
| Finland | 1 | <1% |
| Italy | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 269 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 99 | 35% |
| Researcher | 50 | 18% |
| Student > Bachelor | 31 | 11% |
| Student > Master | 20 | 7% |
| Professor | 14 | 5% |
| Other | 45 | 16% |
| Unknown | 26 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 126 | 44% |
| Biochemistry, Genetics and Molecular Biology | 83 | 29% |
| Medicine and Dentistry | 18 | 6% |
| Physics and Astronomy | 7 | 2% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 2% |
| Other | 15 | 5% |
| Unknown | 31 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 November 2008.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Journal of Cell Biology
#10,621
of 11,939 outputs
Outputs of similar age
#87,593
of 102,136 outputs
Outputs of similar age from Journal of Cell Biology
#52
of 73 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,939 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,136 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 8th percentile – i.e., 8% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 73 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.