GWAS have identified 100s of common variants 🧬associated with estimated BMD (eBMD, a measure of BMD derived from ultrasound of the heel 🦶) https://t.co/oFzdqD7hFW https://t.co/ObBnKgP0RV https://t.co/1XLE6Ak1Oh
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In this preprint the authors started with 1,097 lead SNPs for bone mineral density from https://t.co/8JYxEK0qJZ and applied TWAS and eQTL colocalization to identify "potentially causal genes"
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@cristenw I never suggested that variant effect size = drug effect size. I even wrote a thread on this recently using BMD - osteoporosis drug targets as an example 1/ https://t.co/SqSPEJ2us6
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People often equate GWAS effect size with drug effect size, which is wrong. The GWAS effect size should not be equated to drug effect size. We can magnify the effect size multiple folds using drugs. https://t.co/3CHQTkYZzR https://t.co/FNquKsbH52