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Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

Overview of attention for article published in Neuron, April 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

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7 patents
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1 research highlight platform

Citations

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120 Dimensions

Readers on

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123 Mendeley
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Title
Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers
Published in
Neuron, April 2009
DOI 10.1016/j.neuron.2009.02.020
Pubmed ID
Authors

Marçal Vilar, Ioannis Charalampopoulos, Rajappa S. Kenchappa, Anastasia Simi, Esra Karaca, Alessandra Reversi, Soyoung Choi, Mark Bothwell, Ismael Mingarro, Wilma J. Friedman, Giampietro Schiavo, Philippe I.H. Bastiaens, Peter J. Verveer, Bruce D. Carter, Carlos F. Ibáñez

Abstract

Ligand-mediated dimerization has emerged as a universal mechanism of growth factor receptor activation. Neurotrophins interact with dimers of the p75 neurotrophin receptor (p75(NTR)), but the mechanism of receptor activation has remained elusive. Here, we show that p75(NTR) forms disulphide-linked dimers independently of neurotrophin binding through the highly conserved Cys(257) in its transmembrane domain. Mutation of Cys(257) abolished neurotrophin-dependent receptor activity but did not affect downstream signaling by the p75(NTR)/NgR/Lingo-1 complex in response to MAG, indicating the existence of distinct, ligand-specific activation mechanisms for p75(NTR). FRET experiments revealed a close association of p75(NTR) intracellular domains that was transiently disrupted by conformational changes induced upon NGF binding. Although mutation of Cys(257) did not alter the oligomeric state of p75(NTR), the mutant receptor was no longer able to propagate conformational changes to the cytoplasmic domain upon ligand binding. We propose that neurotrophins activate p75(NTR) by a mechanism involving rearrangement of disulphide-linked receptor subunits.

Mendeley readers

The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 2%
France 2 2%
Chile 1 <1%
Sweden 1 <1%
Venezuela, Bolivarian Republic of 1 <1%
Unknown 116 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 29 24%
Researcher 24 20%
Student > Bachelor 18 15%
Professor 8 7%
Professor > Associate Professor 7 6%
Other 23 19%
Unknown 14 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 48 39%
Biochemistry, Genetics and Molecular Biology 23 19%
Neuroscience 20 16%
Medicine and Dentistry 6 5%
Physics and Astronomy 3 2%
Other 8 7%
Unknown 15 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2021.
All research outputs
#2,646,357
of 20,983,497 outputs
Outputs from Neuron
#3,498
of 8,880 outputs
Outputs of similar age
#25,912
of 249,986 outputs
Outputs of similar age from Neuron
#29
of 101 outputs
Altmetric has tracked 20,983,497 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,880 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.7. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 249,986 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.