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Mendeley readers
Attention Score in Context
| Title |
Transfer of MicroRNAs by Embryonic Stem Cell Microvesicles
|
|---|---|
| Published in |
PLOS ONE, March 2009
|
| DOI | 10.1371/journal.pone.0004722 |
| Pubmed ID | |
| Authors |
Alex Yuan, Erica L. Farber, Ana Lia Rapoport, Desiree Tejada, Roman Deniskin, Novrouz B. Akhmedov, Debora B. Farber |
| Abstract |
Microvesicles are plasma membrane-derived vesicles released into the extracellular environment by a variety of cell types. Originally characterized from platelets, microvesicles are a normal constituent of human plasma, where they play an important role in maintaining hematostasis. Microvesicles have been shown to transfer proteins and RNA from cell to cell and they are also believed to play a role in intercellular communication. We characterized the RNA and protein content of embryonic stem cell microvesicles and show that they can be engineered to carry exogenously expressed mRNA and protein such as green fluorescent protein (GFP). We demonstrate that these engineered microvesicles dock and fuse with other embryonic stem cells, transferring their GFP. Additionally, we show that embryonic stem cells microvesicles contain abundant microRNA and that they can transfer a subset of microRNAs to mouse embryonic fibroblasts in vitro. Since microRNAs are short (21-24 nt), naturally occurring RNAs that regulate protein translation, our findings open up the intriguing possibility that stem cells can alter the expression of genes in neighboring cells by transferring microRNAs contained in microvesicles. Embryonic stem cell microvesicles may be useful therapeutic tools for transferring mRNA, microRNAs, protein, and siRNA to cells and may be important mediators of signaling within stem cell niches. |
Mendeley readers
The data shown below were compiled from readership statistics for 301 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Netherlands | 2 | <1% |
| United Kingdom | 2 | <1% |
| Brazil | 2 | <1% |
| India | 2 | <1% |
| Czechia | 1 | <1% |
| Germany | 1 | <1% |
| Denmark | 1 | <1% |
| Turkey | 1 | <1% |
| Other | 2 | <1% |
| Unknown | 282 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 77 | 26% |
| Student > Ph. D. Student | 68 | 23% |
| Student > Master | 29 | 10% |
| Student > Bachelor | 28 | 9% |
| Student > Doctoral Student | 21 | 7% |
| Other | 51 | 17% |
| Unknown | 27 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 113 | 38% |
| Biochemistry, Genetics and Molecular Biology | 65 | 22% |
| Medicine and Dentistry | 44 | 15% |
| Engineering | 9 | 3% |
| Materials Science | 8 | 3% |
| Other | 25 | 8% |
| Unknown | 37 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 December 2022.
All research outputs
#2,036,919
of 23,275,636 outputs
Outputs from PLOS ONE
#25,943
of 198,864 outputs
Outputs of similar age
#6,188
of 94,684 outputs
Outputs of similar age from PLOS ONE
#87
of 507 outputs
Altmetric has tracked 23,275,636 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 198,864 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.2. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,684 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 507 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.