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Mendeley readers
Attention Score in Context
| Title |
Properties of the Force Exerted by Filopodia and Lamellipodia and the Involvement of Cytoskeletal Components
|
|---|---|
| Published in |
PLOS ONE, October 2007
|
| DOI | 10.1371/journal.pone.0001072 |
| Pubmed ID | |
| Authors |
Dan Cojoc, Francesco Difato, Enrico Ferrari, Rajesh B. Shahapure, Jummi Laishram, Massimo Righi, Enzo M. Di Fabrizio, Vincent Torre |
| Abstract |
During neuronal differentiation, lamellipodia and filopodia explore the environment in search for the correct path to the axon's final destination. Although the motion of lamellipodia and filopodia has been characterized to an extent, little is known about the force they exert. In this study, we used optical tweezers to measure the force exerted by filopodia and lamellipodia with a millisecond temporal resolution. We found that a single filopodium exerts a force not exceeding 3 pN, whereas lamellipodia can exert a force up to 20 pN. Using metabolic inhibitors, we showed that no force is produced in the absence of actin polymerization and that development of forces larger than 3 pN requires microtubule polymerization. These results show that actin polymerization is necessary for force production and demonstrate that not only do neurons process information, but they also act on their environment exerting forces varying from tenths pN to tens of pN. |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 3% |
| Italy | 2 | 2% |
| France | 2 | 2% |
| Germany | 1 | <1% |
| United Kingdom | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 110 | 92% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 31% |
| Researcher | 21 | 18% |
| Professor > Associate Professor | 11 | 9% |
| Student > Bachelor | 9 | 8% |
| Student > Doctoral Student | 8 | 7% |
| Other | 16 | 13% |
| Unknown | 18 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 21% |
| Physics and Astronomy | 21 | 18% |
| Biochemistry, Genetics and Molecular Biology | 16 | 13% |
| Engineering | 13 | 11% |
| Neuroscience | 9 | 8% |
| Other | 19 | 16% |
| Unknown | 17 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 December 2020.
All research outputs
#5,894,611
of 22,846,662 outputs
Outputs from PLOS ONE
#71,055
of 194,888 outputs
Outputs of similar age
#21,754
of 76,344 outputs
Outputs of similar age from PLOS ONE
#115
of 221 outputs
Altmetric has tracked 22,846,662 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 194,888 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.1. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 76,344 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 221 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.