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Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial

Overview of attention for article published in Journal of Applied Oral Science, January 2019
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Title
Evaluating clinical and laboratory effects of ozone in non-surgical periodontal treatment: a randomized controlled trial
Published in
Journal of Applied Oral Science, January 2019
DOI 10.1590/1678-7757-2018-0108
Pubmed ID
Authors

Eltas Seydanur Dengizek, Dundar Serkan, Eltas Abubekir, Karabulut Aysun Bay, Otlu Onder, Cicek Arife

Abstract

This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-β) levels were evaluated from saliva samples. Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-β levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05). The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 97 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 17 18%
Student > Postgraduate 14 14%
Student > Master 6 6%
Student > Ph. D. Student 5 5%
Student > Doctoral Student 5 5%
Other 21 22%
Unknown 29 30%
Readers by discipline Count As %
Medicine and Dentistry 46 47%
Agricultural and Biological Sciences 4 4%
Nursing and Health Professions 3 3%
Veterinary Science and Veterinary Medicine 2 2%
Biochemistry, Genetics and Molecular Biology 2 2%
Other 9 9%
Unknown 31 32%