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High content live cell imaging for the discovery of new antimalarial marine natural products

Overview of attention for article published in BMC Infectious Diseases, January 2012
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Title
High content live cell imaging for the discovery of new antimalarial marine natural products
Published in
BMC Infectious Diseases, January 2012
DOI 10.1186/1471-2334-12-1
Pubmed ID
Authors

Serena Cervantes, Paige E Stout, Jacques Prudhomme, Sebastian Engel, Matthew Bruton, Michael Cervantes, David Carter, Young Tae-Chang, Mark E Hay, William Aalbersberg, Julia Kubanek, Karine G Le Roch

Abstract

The human malaria parasite remains a burden in developing nations. It is responsible for up to one million deaths a year, a number that could rise due to increasing multi-drug resistance to all antimalarial drugs currently available. Therefore, there is an urgent need for the discovery of new drug therapies. Recently, our laboratory developed a simple one-step fluorescence-based live cell-imaging assay to integrate the complex biology of the human malaria parasite into drug discovery. Here we used our newly developed live cell-imaging platform to discover novel marine natural products and their cellular phenotypic effects against the most lethal malaria parasite, Plasmodium falciparum.

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The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 3 4%
Mexico 1 1%
Unknown 66 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 17 24%
Student > Ph. D. Student 10 14%
Student > Master 6 9%
Lecturer 5 7%
Other 5 7%
Other 16 23%
Unknown 11 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 36%
Chemistry 9 13%
Biochemistry, Genetics and Molecular Biology 8 11%
Medicine and Dentistry 5 7%
Engineering 3 4%
Other 8 11%
Unknown 12 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 January 2012.
All research outputs
#20,153,989
of 22,661,413 outputs
Outputs from BMC Infectious Diseases
#6,417
of 7,633 outputs
Outputs of similar age
#221,289
of 244,202 outputs
Outputs of similar age from BMC Infectious Diseases
#66
of 77 outputs
Altmetric has tracked 22,661,413 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,633 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,202 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 77 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.