@ABsteward There aren’t any Colistin “susceptible” breakpoints for Acinetobacter per CLSI. I think the main issue with colistin is achieving adequate concentrations in areas outside of the urinary tract. This is a good summary of the PK/PD data https://t.c
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Esp since it has a narrow therapeutic window and the 2019 guidelines suggest a Css of 2 mg/L https://t.co/RlVUAvpgmy https://t.co/3nrLiedhXG
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International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infect Diseases Society of America IDSA https://t.co/NziUy7eHeZ
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RT @khalid_eljaaly2: 🔥 وأخيرا نزلت توصيات خاصة بالكولستين طال انتظارها. أغلب من جهزها صيادلة أمراض معدية. انشروها لتعم الفائدة: https://t.c…