Title |
Transbilayer phospholipids molecular imaging
|
---|---|
Published in |
EJNMMI Research, August 2011
|
DOI | 10.1186/2191-219x-1-17 |
Pubmed ID | |
Authors |
Tarik Z Belhocine, Frank S Prato |
Abstract |
Nuclear medicine has become a key part of molecular imaging. In the present review article, we focus on the transbilayer phospholipids as exquisite targets for radiolabelled probes in molecular imaging. Asymmetry of phospholipid distribution is a characteristic of mammalian cell membranes. Phosphatidylcholine and sphyngomyelin cholinophospholipids are primarily located within the external leaflet of the cell membrane. Phosphatidylserine and phosphatidylethanolamine aminophospholipids, and also phosphatidylinositol are primarily located within the internal leaflet of the cell membrane. New radiolabelled tracers have been designed in preclinical and clinical research for PET-CT and SPECT-CT molecular imaging of transbilayer phospholipids. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 4% |
Canada | 1 | 4% |
Unknown | 24 | 92% |
Demographic breakdown
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Researcher | 9 | 35% |
Student > Doctoral Student | 3 | 12% |
Student > Bachelor | 3 | 12% |
Student > Ph. D. Student | 3 | 12% |
Professor > Associate Professor | 2 | 8% |
Other | 3 | 12% |
Unknown | 3 | 12% |
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Agricultural and Biological Sciences | 6 | 23% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 8% |
Chemistry | 2 | 8% |
Other | 2 | 8% |
Unknown | 3 | 12% |