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High incidence of tuberculosis in patients treated for hepatitis C chronic infection

Overview of attention for article published in Brazilian Journal of Infectious Diseases, March 2016
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (58th percentile)
  • Good Attention Score compared to outputs of the same age and source (70th percentile)

Mentioned by

twitter
3 tweeters

Citations

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12 Dimensions

Readers on

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47 Mendeley
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Title
High incidence of tuberculosis in patients treated for hepatitis C chronic infection
Published in
Brazilian Journal of Infectious Diseases, March 2016
DOI 10.1016/j.bjid.2015.12.003
Pubmed ID
Authors

Silvia Naomi de Oliveira Uehara, Christini Takemi Emori, Renata Mello Perez, Maria Cassia Jacintho Mendes-Correa, Adalgisa de Souza Paiva Ferreira, Ana Cristina de Castro Amaral Feldner, Antonio Eduardo Benedito Silva, Roberto José Carvalho Filho, Ivonete Sandra de Souza e Silva, Maria Lucia Cardoso Gomes Ferraz

Abstract

Brazil is one of the 22 countries that concentrates 80% of global tuberculosis cases concomitantly to a large number of hepatitis C carriers and some epidemiological risk scenarios are coincident for both diseases. We analyzed tuberculosis cases that occurred during α-interferon-based therapy for hepatitis C in reference centers in Brazil between 2001 and 2012 and reviewed their medical records. Eighteen tuberculosis cases were observed in patients submitted to hepatitis C α-interferon-based therapy. All patients were human immunodeficiency virus-negative. Nine patients (50%) had extra-pulmonary tuberculosis; 15 (83%) showed significant liver fibrosis. Hepatitis C treatment was discontinued in 12 patients (67%) due to tuberculosis reactivation and six (33%) had sustained virological response. The majority of patients had a favorable outcome but one died. Considering the evidences of α-IFN interference over the containment of Mycobacterium tuberculosis, the immune impairment of cirrhotic patients, the increase of tuberculosis case reports during hepatitis C treatment with atypical and severe presentations and the negative impact on sustained virological response, we think these are strong arguments for latent tuberculosis infection screening before starting α-interferon-based therapy for any indication and even to consider IFN-free regimens against hepatitis C when a patient tests positive for latent tuberculosis infection.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 2%
Unknown 46 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 17%
Student > Ph. D. Student 6 13%
Researcher 4 9%
Student > Doctoral Student 4 9%
Lecturer 3 6%
Other 11 23%
Unknown 11 23%
Readers by discipline Count As %
Medicine and Dentistry 18 38%
Immunology and Microbiology 4 9%
Agricultural and Biological Sciences 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Biochemistry, Genetics and Molecular Biology 3 6%
Other 3 6%
Unknown 13 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2021.
All research outputs
#9,940,604
of 18,096,829 outputs
Outputs from Brazilian Journal of Infectious Diseases
#194
of 548 outputs
Outputs of similar age
#143,966
of 353,787 outputs
Outputs of similar age from Brazilian Journal of Infectious Diseases
#3
of 10 outputs
Altmetric has tracked 18,096,829 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 548 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 64% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,787 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.
We're also able to compare this research output to 10 others from the same source and published within six weeks on either side of this one. This one has scored higher than 7 of them.