Title |
Identification and proteomic profiling of exosomes in human cerebrospinal fluid
|
---|---|
Published in |
Journal of Translational Medicine, January 2012
|
DOI | 10.1186/1479-5876-10-5 |
Pubmed ID | |
Authors |
Jonathan M Street, Perdita E Barran, C Logan Mackay, Stefan Weidt, Craig Balmforth, Tim S Walsh, Rod TA Chalmers, David J Webb, James W Dear |
Abstract |
Exosomes are released from multiple cell types, contain protein and RNA species, and have been exploited as a novel reservoir for disease biomarker discovery. They can transfer information between cells and may cause pathology, for example, a role for exosomes has been proposed in the pathophysiology of Alzheimer's disease. Although studied in several biofluids, exosomes have not been extensively studied in the cerebrospinal fluid (CSF) from humans. The objective of this study was to determine: 1) whether human CSF contains exosomes and 2) the variability in exosomal protein content across individuals. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Japan | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 1% |
Italy | 1 | <1% |
Australia | 1 | <1% |
Netherlands | 1 | <1% |
Belgium | 1 | <1% |
Brazil | 1 | <1% |
Spain | 1 | <1% |
Denmark | 1 | <1% |
Unknown | 420 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 84 | 19% |
Student > Ph. D. Student | 83 | 19% |
Student > Master | 53 | 12% |
Student > Bachelor | 39 | 9% |
Professor > Associate Professor | 22 | 5% |
Other | 60 | 14% |
Unknown | 92 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 91 | 21% |
Biochemistry, Genetics and Molecular Biology | 85 | 20% |
Medicine and Dentistry | 52 | 12% |
Neuroscience | 37 | 9% |
Immunology and Microbiology | 13 | 3% |
Other | 48 | 11% |
Unknown | 107 | 25% |