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Earthworm-mediated synthesis of silver nanoparticles: A potent tool against hepatocellular carcinoma, Plasmodium falciparum parasites and malaria mosquitoes

Overview of attention for article published in Parasitology International, February 2016
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  • Above-average Attention Score compared to outputs of the same age (52nd percentile)
  • High Attention Score compared to outputs of the same age and source (99th percentile)

Mentioned by

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7 X users

Citations

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70 Dimensions

Readers on

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103 Mendeley
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Title
Earthworm-mediated synthesis of silver nanoparticles: A potent tool against hepatocellular carcinoma, Plasmodium falciparum parasites and malaria mosquitoes
Published in
Parasitology International, February 2016
DOI 10.1016/j.parint.2016.02.003
Pubmed ID
Authors

Anitha Jaganathan, Kadarkarai Murugan, Chellasamy Panneerselvam, Pari Madhiyazhagan, Devakumar Dinesh, Chithravel Vadivalagan, Al Thabiani Aziz, Balamurugan Chandramohan, Udaiyan Suresh, Rajapandian Rajaganesh, Jayapal Subramaniam, Marcello Nicoletti, Akon Higuchi, Abdullah A. Alarfaj, Murugan A. Munusamy, Suresh Kumar, Giovanni Benelli

Abstract

The development of parasites and pathogens resistant to synthetic drugs highlighted the needing of novel, eco-friendly and effective control approaches. Recently, metal nanoparticles have been proposed as highly effective tools towards cancer cells and Plasmodium parasites. In this study, we synthesized silver nanoparticles (EW-AgNP) using Eudrilus eugeniae earthworms as reducing and stabilizing agents. EW-AgNP showed plasmon resonance reduction in UV-vis spectrophotometry, the functional groups involved in the reduction were studied by FTIR spectroscopy, while particle size and shape was analyzed by FESEM. The effect of EW-AgNP on in vitro HepG2 cell proliferation was measured using MTT assays. Apoptosis assessed by flow cytometry showed diminished endurance of HepG2 cells and cytotoxicity in a dose-dependent manner. EW-AgNP were toxic to Anopheles stephensi larvae and pupae, LC50 were 4.8ppm (I), 5.8ppm (II), 6.9ppm (III), 8.5ppm (IV), and 15.5ppm (pupae). The antiplasmodial activity of EW-AgNP was evaluated against CQ-resistant (CQ-r) and CQ-sensitive (CQ-s) strains of Plasmodium falciparum. EW-AgNP IC50 were 49.3μg/ml (CQ-s) and 55.5μg/ml (CQ-r), while chloroquine IC50 were 81.5μg/ml (CQ-s) and 86.5μg/ml (CQ-r). EW-AgNP showed a valuable antibiotic potential against important pathogenic bacteria and fungi. Concerning non-target effects of EW-AgNP against mosquito natural enemies, the predation efficiency of the mosquitofish Gambusia affinis towards the II and II instar larvae of A. stephensi was 68.50% (II) and 47.00% (III), respectively. In EW-AgNP-contaminated environments, predation was boosted to 89.25% (II) and 70.75% (III), respectively. Overall, this research highlighted the EW-AgNP potential against hepatocellular carcinoma, Plasmodium parasites and mosquito vectors, with little detrimental effects on mosquito natural enemies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Mexico 1 <1%
Unknown 101 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 20 19%
Researcher 12 12%
Student > Bachelor 8 8%
Student > Master 7 7%
Student > Doctoral Student 6 6%
Other 20 19%
Unknown 30 29%
Readers by discipline Count As %
Agricultural and Biological Sciences 15 15%
Medicine and Dentistry 9 9%
Biochemistry, Genetics and Molecular Biology 8 8%
Pharmacology, Toxicology and Pharmaceutical Science 6 6%
Materials Science 5 5%
Other 27 26%
Unknown 33 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 December 2017.
All research outputs
#14,393,001
of 25,383,225 outputs
Outputs from Parasitology International
#415
of 1,210 outputs
Outputs of similar age
#193,500
of 411,100 outputs
Outputs of similar age from Parasitology International
#1
of 13 outputs
Altmetric has tracked 25,383,225 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,210 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 411,100 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.