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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Global Analysis of Small Molecule Binding to Related Protein Targets
|
|---|---|
| Published in |
PLoS Computational Biology, January 2012
|
| DOI | 10.1371/journal.pcbi.1002333 |
| Pubmed ID | |
| Authors |
Felix A. Kruger, John P. Overington |
| Abstract |
We report on the integration of pharmacological data and homology information for a large scale analysis of small molecule binding to related targets. Differences in small molecule binding have been assessed for curated pairs of human to rat orthologs and also for recently diverged human paralogs. Our analysis shows that in general, small molecule binding is conserved for pairs of human to rat orthologs. Using statistical tests, we identified a small number of cases where small molecule binding is different between human and rat, some of which had previously been reported in the literature. Knowledge of species specific pharmacology can be advantageous for drug discovery, where rats are frequently used as a model system. For human paralogs, we demonstrate a global correlation between sequence identity and the binding of small molecules with equivalent affinity. Our findings provide an initial general model relating small molecule binding and sequence divergence, containing the foundations for a general model to anticipate and predict within-target-family selectivity. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Switzerland | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 5% |
| United States | 5 | 5% |
| Germany | 2 | 2% |
| Israel | 1 | <1% |
| Denmark | 1 | <1% |
| Portugal | 1 | <1% |
| Spain | 1 | <1% |
| Poland | 1 | <1% |
| Unknown | 89 | 84% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 41 | 39% |
| Student > Ph. D. Student | 21 | 20% |
| Student > Bachelor | 9 | 8% |
| Student > Master | 8 | 8% |
| Other | 8 | 8% |
| Other | 17 | 16% |
| Unknown | 2 | 2% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 37 | 35% |
| Biochemistry, Genetics and Molecular Biology | 19 | 18% |
| Chemistry | 17 | 16% |
| Computer Science | 9 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 10 | 9% |
| Unknown | 8 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2012.
All research outputs
#2,852,117
of 25,754,670 outputs
Outputs from PLoS Computational Biology
#2,523
of 9,032 outputs
Outputs of similar age
#21,034
of 250,764 outputs
Outputs of similar age from PLoS Computational Biology
#16
of 123 outputs
Altmetric has tracked 25,754,670 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,032 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 250,764 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 91% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.