Title |
Strabismus-mediated primary archenteron invagination is uncoupled from Wnt/β-catenin-dependent endoderm cell fate specification in Nematostella vectensis (Anthozoa, Cnidaria): Implications for the evolution of gastrulation
|
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Published in |
EvoDevo, January 2011
|
DOI | 10.1186/2041-9139-2-2 |
Pubmed ID | |
Authors |
Shalika Kumburegama, Naveen Wijesena, Ronghui Xu, Athula H Wikramanayake |
Abstract |
Gastrulation is a uniquely metazoan character, and its genesis was arguably the key step that enabled the remarkable diversification within this clade. The process of gastrulation involves two tightly coupled events during embryogenesis of most metazoans. Morphogenesis produces a distinct internal epithelial layer in the embryo, and this epithelium becomes segregated as an endoderm/endomesodermal germ layer through the activation of a specific gene regulatory program. The developmental mechanisms that induced archenteron formation and led to the segregation of germ layers during metazoan evolution are unknown. But an increased understanding of development in early diverging taxa at the base of the metazoan tree may provide insights into the origins of these developmental mechanisms. |
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Readers by professional status | Count | As % |
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Researcher | 16 | 19% |
Student > Master | 11 | 13% |
Student > Bachelor | 10 | 12% |
Professor > Associate Professor | 4 | 5% |
Other | 12 | 14% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
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Physics and Astronomy | 2 | 2% |
Environmental Science | 2 | 2% |
Materials Science | 2 | 2% |
Other | 2 | 2% |
Unknown | 15 | 18% |