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Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy

Overview of attention for article published in Drug Design, Development and Therapy, February 2016
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

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5 tweeters

Citations

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47 Dimensions

Readers on

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28 Mendeley
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Title
Protective effect of fucoidan from Fucus vesiculosus on liver fibrosis via the TGF-β1/Smad pathway-mediated inhibition of extracellular matrix and autophagy
Published in
Drug Design, Development and Therapy, February 2016
DOI 10.2147/dddt.s98740
Pubmed ID
Authors

Chuanyong Guo, Jingjing Li, Kan Chen, Sainan Li, Jiao Feng, Tong Liu, Fan Wang, Rong Zhang, Shizan Xu, Yuqing Zhou, Shunfeng Zhou, Yujing Xia, Jie Lu, Yingqun Zhou

Abstract

Liver fibrosis is a dynamic reversible pathological process in the development of chronic liver disease to cirrhosis. However, the current treatments are not administered for a long term due to their various side effects. Autophagy is initiated to decompose damaged or excess organelles, which had been found to alter the progression of liver fibrosis. In this article, we hypothesized that fucoidan from Fucus vesiculosus may attenuate liver fibrosis in mice by inhibition of the extracellular matrix and autophagy in carbon tetrachloride- and bile duct ligation-induced animal models of liver fibrosis. The results were determined using enzyme-linked immunosorbent assay, quantitative real-time polymerase chain reaction, Western blotting, and immunohistochemical staining. Fucoidan from F. vesiculosus could inhibit the activation of hepatic stellate cells and the formation of extracellular matrix and autophagosomes, and its effect may be associated with the downregulation of transforming growth factor beta 1/Smads pathways. Fucoidan, as an autophagy and transforming growth factor beta 1 inhibitor, could be a promising potential therapeutic agent for liver fibrosis.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 21%
Student > Master 3 11%
Student > Bachelor 3 11%
Researcher 2 7%
Student > Doctoral Student 2 7%
Other 4 14%
Unknown 8 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 8 29%
Agricultural and Biological Sciences 4 14%
Medicine and Dentistry 2 7%
Business, Management and Accounting 1 4%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 2 7%
Unknown 10 36%

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 April 2016.
All research outputs
#1,836,433
of 7,584,550 outputs
Outputs from Drug Design, Development and Therapy
#147
of 977 outputs
Outputs of similar age
#98,470
of 326,779 outputs
Outputs of similar age from Drug Design, Development and Therapy
#15
of 85 outputs
Altmetric has tracked 7,584,550 research outputs across all sources so far. This one has received more attention than most of these and is in the 62nd percentile.
So far Altmetric has tracked 977 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,779 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 85 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.