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Vaccine model of antiphospholipid syndrome induced by tetanus vaccine

Overview of attention for article published in Lupus, January 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • One of the highest-scoring outputs from this source (#9 of 1,717)
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (80th percentile)

Mentioned by

news
3 news outlets
twitter
53 tweeters
facebook
185 Facebook pages
googleplus
6 Google+ users

Citations

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20 Dimensions

Readers on

mendeley
27 Mendeley
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Title
Vaccine model of antiphospholipid syndrome induced by tetanus vaccine
Published in
Lupus, January 2012
DOI 10.1177/0961203311429816
Pubmed ID
Authors

L Dimitrijević, I Živković, M Stojanović, V Petrušić, S Živančević-Simonović

Abstract

Successful induction of antiphospholipid syndrome (APS) in two different non-autoimmune prone mouse strains, BALB/c and C57BL/6, was achieved by tetanus toxoid (TTd) hyperimmunization using different adjuvants (glycerol or aluminium hydroxide), and different adjuvant pretreatments (glycerol or Complete Freund's Adjuvant (CFA)). APS had different manifestations of reproductive pathology in BALB/c and C57BL/6 mice: fetal resorption (as a consequence of extreme T-cell activation obtained in the course of pretreatment), and lowering of fecundity (as a consequence of polyclonal B-cell stimulation), respectively. In BALB/c mice fetal resorption coincided with glycerol and CFA pretreatments, while in C57BL/6 mice lowering of fecundity was most obvious in CFA-pretreated mice immunized with TTd in aluminium hydroxide. Both molecular mimicry and polyclonal B-cell activation occur in APS induction, with molecular mimicry effects being dominant in BALB/c mice, and polyclonal cell activation being dominant in C57BL/6 mice. Confirmation of molecular mimicry effects, which in the condition of T-cell stimulation generated fetal resorptions in the BALB/c strain, was achieved by passive infusion of monoclonal antibody (MoAb) T-26 specific for TTd and anti-β(2)-glycoprotein I obtained after TTd hyperimunization. High polyclonal B-cell activation in C57BL/6 mice prevented fetal resorption but induced fecundity lowering, as was the case in passive administration of MoAb T-26 in this mouse strain. Passive infusion of anti-idiotypic MoAb Y7 into C57BL/6 mice induced fetal resorptions and confirmed the above suggestion on the protective role of polyclonal B-cell stimulation in fetal resorptions.

Twitter Demographics

The data shown below were collected from the profiles of 53 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 4%
Australia 1 4%
Unknown 25 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 33%
Other 6 22%
Student > Ph. D. Student 2 7%
Student > Master 2 7%
Student > Bachelor 1 4%
Other 3 11%
Unknown 4 15%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 33%
Medicine and Dentistry 4 15%
Immunology and Microbiology 3 11%
Biochemistry, Genetics and Molecular Biology 1 4%
Sports and Recreations 1 4%
Other 1 4%
Unknown 8 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 107. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 October 2022.
All research outputs
#322,448
of 22,491,736 outputs
Outputs from Lupus
#9
of 1,717 outputs
Outputs of similar age
#2,039
of 256,228 outputs
Outputs of similar age from Lupus
#6
of 31 outputs
Altmetric has tracked 22,491,736 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,717 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.3. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 256,228 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.