Chapter title |
Enzymic and interindividual differences in the human metabolism of heterocyclic amines.
|
---|---|
Chapter number | 28 |
Book title |
Toxicology - From Cells to Man
|
Published in |
Archives of toxicology Supplement Archiv für Toxikologie Supplement, January 1996
|
DOI | 10.1007/978-3-642-61105-6_28 |
Pubmed ID | |
Book ISBNs |
978-3-64-264696-6, 978-3-64-261105-6
|
Authors |
Alan R. Boobis, Nigel J. Gooderham, Robert J. Edwards, Stephen Murray, Anthony M. Lynch, Masoud Yadollahi-Farsani, Donald S. Davies, Boobis, Alan R., Gooderham, Nigel J., Edwards, Robert J., Murray, Stephen, Lynch, Anthony M., Yadollahi-Farsani, Masoud, Davies, Donald S. |
Abstract |
Heterocyclic amines (HAs) present in cooked meat (PhIP and MeIQx) are activated only by CYP1A2 in the liver of most species, including man. This enzyme exhibits marked interindividual differences in its expression, due to induction and possibly also genetically. The absence of CYP1A2 appears to protect from HA-(PhIP and MeIQx) induced cancer, as exemplified by results in the cynomolgus monkey. Differences in the potency of these HAs are not due to differences in the kinetics of their activation. The catalytic efficiency of CYP1A2 towards HAs and their oxidative fate varies amongst species, in both cases increasing the susceptibility of humans compared to that of the rat. Interindividual and inter-organ differences in the further metabolism of N-hydroxy-HAs appear to be important determinants of cancer susceptibility, as does the glutathione S-transferase catalysed detoxication of esters of N-hydroxy-PhIP. There is a need for an effective means of quantifying the in vivo activation of HAs in man to enable the possible risk posed by these compounds to be assessed effectively. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor | 5 | 45% |
Student > Ph. D. Student | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Lecturer > Senior Lecturer | 1 | 9% |
Researcher | 1 | 9% |
Other | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 4 | 36% |
Agricultural and Biological Sciences | 3 | 27% |
Medicine and Dentistry | 2 | 18% |
Nursing and Health Professions | 1 | 9% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Other | 1 | 9% |