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Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide

Overview of attention for article published in Jornal de Pediatria, May 2016
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#17 of 569)
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (92nd percentile)

Mentioned by

blogs
2 blogs
twitter
1 tweeter

Citations

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3 Dimensions

Readers on

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58 Mendeley
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Title
Improvement of autism spectrum disorder symptoms in three children by using gastrin-releasing peptide
Published in
Jornal de Pediatria, May 2016
DOI 10.1016/j.jped.2015.08.012
Pubmed ID
Authors

Michele Michelin Becker, Cleonice Bosa, Vera Lorentz Oliveira-Freitas, José Roberto Goldim, Lygia Ohlweiler, Rafael Roesler, Gilberto Schwartsmann, Rudimar dos Santos Riesgo

Abstract

To evaluate the safety, tolerability and potential therapeutic effects of gastrin-releasing peptide in three children with autistic spectrum disorder. Case series study with the intravenous administration of gastrin-releasing peptide in the dose of 160pmol/kg for four consecutive days. To evaluate the results, parental impressions the Childhood Autism Rating Scale (CARS) and the Clinical Global Impression (CGI) Scale. Each child underwent a new peptide cycle after two weeks. The children were followed for four weeks after the end of the infusions. The gastrin-releasing peptide was well tolerated and no child had adverse effects. Two children had improved social interaction, with a slight improvement in joint attention and the interaction initiatives. Two showed reduction of stereotypes and improvement in verbal language. One child lost his compulsion to bathe, an effect that lasted two weeks after each infusion cycle. Average reduction in CARS score was 2.8 points. CGI was "minimally better" in two children and "much better" in one. This study suggests that the gastrin-releasing peptide is safe and may be effective in improving key symptoms of autism spectrum disorder, but its results should be interpreted with caution. Controlled clinical trials-randomized, double-blinded, and with more children-are needed to better evaluate the possible therapeutic effects of gastrin-releasing peptide in autism.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 58 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 21%
Student > Bachelor 10 17%
Researcher 9 16%
Student > Postgraduate 5 9%
Student > Ph. D. Student 4 7%
Other 4 7%
Unknown 14 24%
Readers by discipline Count As %
Nursing and Health Professions 12 21%
Psychology 12 21%
Medicine and Dentistry 7 12%
Arts and Humanities 4 7%
Social Sciences 3 5%
Other 4 7%
Unknown 16 28%

Attention Score in Context

This research output has an Altmetric Attention Score of 14. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2016.
All research outputs
#1,287,334
of 14,354,509 outputs
Outputs from Jornal de Pediatria
#17
of 569 outputs
Outputs of similar age
#36,605
of 342,166 outputs
Outputs of similar age from Jornal de Pediatria
#1
of 14 outputs
Altmetric has tracked 14,354,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 569 research outputs from this source. They receive a mean Attention Score of 3.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,166 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.