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Mendeley readers
Attention Score in Context
| Title |
A network of synaptic genes associated with schizophrenia and bipolar disorder
|
|---|---|
| Published in |
Schizophrenia Research, February 2016
|
| DOI | 10.1016/j.schres.2016.02.012 |
| Pubmed ID | |
| Authors |
Diego A. Forero, Liesbet Herteleer, Sonia De Zutter, Karl-Fredrik Norrback, Lars-Göran Nilsson, Rolf Adolfsson, Patrick Callaerts, Jurgen Del-Favero |
| Abstract |
Identification of novel candidate genes for schizophrenia (SZ) and bipolar disorder (BP), two psychiatric disorders with large epidemiological impacts, is a key research area in neurosciences and psychiatric genetics. Previous evidence from genome-wide studies suggests an important role for genes involved in synaptic plasticity in the risk for SZ and BP. We used a convergent genomics approach, combining different lines of biological evidence, to identify genes involved in the cAMP/PKA/CREB functional pathway that could be novel candidates for BP and SZ: CREB1, CREM, GRIN2C, NPY2R, NF1, PPP3CB and PRKAR1A. These 7 genes were analyzed in a HapMap based association study comprising 48 common SNPs in 486 SZ, 351 BP patients and 514 control individuals recruited from an isolated population in Northern Sweden. Genetic analysis showed significant allelic associations of SNPs in PRKAR1A with SZ and of PPP3CB and PRKAR1A with BP. Our results highlight the feasibility and the importance of convergent genomic data analysis for the identification of candidate genes and our data provide support for the role of common inherited variants in synaptic genes and their involvement in the etiology of BP and SZ. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Belgium | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 2% |
| Unknown | 57 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 22% |
| Researcher | 9 | 16% |
| Student > Bachelor | 7 | 12% |
| Student > Master | 6 | 10% |
| Student > Doctoral Student | 4 | 7% |
| Other | 10 | 17% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 12 | 21% |
| Medicine and Dentistry | 10 | 17% |
| Psychology | 7 | 12% |
| Agricultural and Biological Sciences | 5 | 9% |
| Biochemistry, Genetics and Molecular Biology | 4 | 7% |
| Other | 5 | 9% |
| Unknown | 15 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 April 2016.
All research outputs
#14,913,921
of 25,373,627 outputs
Outputs from Schizophrenia Research
#2,945
of 5,686 outputs
Outputs of similar age
#205,149
of 412,529 outputs
Outputs of similar age from Schizophrenia Research
#38
of 110 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,686 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 412,529 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 63% of its contemporaries.