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Mendeley readers
Attention Score in Context
| Title |
The PI3K signaling pathway as a pharmacological target in Autism related disorders and Schizophrenia
|
|---|---|
| Published in |
Molecular and Cellular Therapies, February 2016
|
| DOI | 10.1186/s40591-016-0047-9 |
| Pubmed ID | |
| Authors |
Lilian Enriquez-Barreto, Miguel Morales |
| Abstract |
This review is focused in PI3K's involvement in two widespread mental disorders: Autism and Schizophrenia. A large body of evidence points to synaptic dysfunction as a cause of these diseases, either during the initial phases of brain synaptic circuit's development or later modulating synaptic function and plasticity. Autism related disorders and Schizophrenia are complex genetic conditions in which the identification of gene markers has proved difficult, although the existence of single-gene mutations with a high prevalence in both diseases offers insight into the role of the PI3K signaling pathway. In the brain, components of the PI3K pathway regulate synaptic formation and plasticity; thus, disruption of this pathway leads to synapse dysfunction and pathological behaviors. Here, we recapitulate recent evidences that demonstrate the imbalance of several PI3K elements as leading causes of Autism and Schizophrenia, together with the plausible new pharmacological paths targeting this signaling pathway. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 109 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 24 | 22% |
| Researcher | 18 | 17% |
| Student > Master | 13 | 12% |
| Student > Bachelor | 13 | 12% |
| Student > Doctoral Student | 10 | 9% |
| Other | 8 | 7% |
| Unknown | 23 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 24 | 22% |
| Biochemistry, Genetics and Molecular Biology | 23 | 21% |
| Agricultural and Biological Sciences | 17 | 16% |
| Medicine and Dentistry | 8 | 7% |
| Computer Science | 2 | 2% |
| Other | 10 | 9% |
| Unknown | 25 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 February 2024.
All research outputs
#20,723,696
of 25,457,297 outputs
Outputs from Molecular and Cellular Therapies
#30
of 36 outputs
Outputs of similar age
#304,189
of 410,507 outputs
Outputs of similar age from Molecular and Cellular Therapies
#3
of 3 outputs
Altmetric has tracked 25,457,297 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 36 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.6. This one scored the same or higher as 6 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 410,507 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one.