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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer’s disease
|
|---|---|
| Published in |
Scientific Reports, February 2016
|
| DOI | 10.1038/srep21568 |
| Pubmed ID | |
| Authors |
Leah C. Graham, Jeffrey M. Harder, Ileana Soto, Wilhelmine N. de Vries, Simon W. M. John, Gareth R. Howell |
| Abstract |
Studies have assessed individual components of a western diet, but no study has assessed the long-term, cumulative effects of a western diet on aging and Alzheimer's disease (AD). Therefore, we have formulated the first western-style diet that mimics the fat, carbohydrate, protein, vitamin and mineral levels of western diets. This diet was fed to aging C57BL/6J (B6) mice to identify phenotypes that may increase susceptibility to AD, and to APP/PS1 mice, a mouse model of AD, to determine the effects of the diet in AD. Astrocytosis and microglia/monocyte activation were dramatically increased in response to diet and was further increased in APP/PS1 mice fed the western diet. This increase in glial responses was associated with increased plaque burden in the hippocampus. Interestingly, given recent studies highlighting the importance of TREM2 in microglia/monocytes in AD susceptibility and progression, B6 and APP/PS1 mice fed the western diet showed significant increases TREM2+ microglia/monocytes. Therefore, an increase in TREM2+ microglia/monocytes may underlie the increased risk from a western diet to age-related neurodegenerative diseases such as Alzheimer's disease. This study lays the foundation to fully investigate the impact of a western diet on glial responses in aging and Alzheimer's disease. |
X Demographics
The data shown below were collected from the profiles of 31 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 23% |
| United Kingdom | 4 | 13% |
| Bulgaria | 1 | 3% |
| Germany | 1 | 3% |
| Canada | 1 | 3% |
| Netherlands | 1 | 3% |
| Switzerland | 1 | 3% |
| Sweden | 1 | 3% |
| Unknown | 14 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 58% |
| Scientists | 7 | 23% |
| Practitioners (doctors, other healthcare professionals) | 6 | 19% |
Mendeley readers
The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Switzerland | 1 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| France | 1 | <1% |
| Unknown | 163 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 22% |
| Student > Bachelor | 27 | 16% |
| Researcher | 23 | 14% |
| Student > Master | 19 | 11% |
| Student > Doctoral Student | 10 | 6% |
| Other | 21 | 12% |
| Unknown | 32 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 39 | 23% |
| Agricultural and Biological Sciences | 27 | 16% |
| Biochemistry, Genetics and Molecular Biology | 18 | 11% |
| Medicine and Dentistry | 14 | 8% |
| Nursing and Health Professions | 6 | 4% |
| Other | 28 | 17% |
| Unknown | 37 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 79. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 July 2021.
All research outputs
#455,226
of 22,832,057 outputs
Outputs from Scientific Reports
#5,138
of 123,280 outputs
Outputs of similar age
#8,961
of 298,027 outputs
Outputs of similar age from Scientific Reports
#203
of 3,491 outputs
Altmetric has tracked 22,832,057 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 123,280 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 298,027 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 3,491 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.