Loose inter-pentamer contacts and/or unstable genome structure lead to capsid opening - either by cracking open or by expulsion of a pentamer (similarly as Echovirus 30 https://t.co/bgMAXFBfMZ) https://t.co/qaWoPfdlZS
@David_Sohaj, @PlevkaLab and @LabVacha showed the mechanism of enterovirus genome release from a capsid shell. Enteroviruses expel one, two, or three adjacent capsid pentamers. RNA genome is released through the hole formed in the capsid: https://t.co/PTqR
The mechanism of genome release by pentamer expulsion was described on human echovirus 18 by our lab earlier - learn more here: "Enterovirus particles expel capsid pentamers to enable genome release" https://t.co/31BS5nfa1S https://t.co/uRwehQ7AEB