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The role of human adenoviruses type 41 in acute diarrheal disease in Minas Gerais after rotavirus vaccination

Overview of attention for article published in Brazilian Journal of Microbiology, January 2016
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Title
The role of human adenoviruses type 41 in acute diarrheal disease in Minas Gerais after rotavirus vaccination
Published in
Brazilian Journal of Microbiology, January 2016
DOI 10.1016/j.bjm.2015.11.011
Pubmed ID
Authors

Thaís Aparecida Vieira Reis, Andrêssa Silvino Ferreira Assis, Daniel Almeida do Valle, Vívian Honorato Barletta, Iná Pires de Carvalho, Tatiana Lundgren Rose, Silvana Augusta Rodrigues Portes, José Paulo Gagliardi Leite, Maria Luzia da Rosa e Silva

Abstract

Human adenovirus species F (HAdV-F) type 40 and 41 are commonly associated with acute diarrheal disease (ADD) across the world. Despite being the largest state in southeastern Brazil and having the second largest number of inhabitants, there is no information in the State of Minas Gerais regarding the role of HAdV-F in the etiology of ADD. This study was performed to determine the prevalence, to verify the epidemiological aspects of infection, and to characterize the strains of human adenoviruses (HAdV) detected. A total of 377 diarrheal fecal samples were obtained between January 2007 and August 2011 from inpatient and outpatient children of age ranging from 0 to 12 years. All samples were previously tested for rotavirus, norovirus, and astrovirus, and 314 of 377 were negative. The viral DNA was extracted, amplified using the polymerase chain reaction and the HAdV-positive samples were sequenced and phylogenetically analyzed. Statistical analyses were performed using the Chi-square test (p<0.05), considering two conditions: the total of samples tested (377) and the total of negative samples for the remaining viruses tested (314). The overall prevalence of HAdV was 12.47% (47/377); and in 76.60% (36/47) of the positive samples, this virus was the only infectious agent detected. The phylogenetic analysis of partial sequences of 32 positive samples revealed that they all clustered with the HAdV-F type 41. The statistical analysis showed that there was no correlation between the onset of the HAdV infection and the origin of the samples (inpatients or outpatients) in the two conditions tested: the total of samples tested (p=0.598) and the total of negative samples for the remaining viruses tested (p=0.614). There was a significant association in the occurrence of infection in children aged 0-12 months for the condition 1 (p=0.030) as well as condition 2 (p=0.019). The occurrence of infections due to HAdV did not coincide with a pattern of seasonal distribution. These data indicate the significant involvement of HAdV-F type 41 in the etiology of ADD in Minas Gerais, which demonstrates the importance of other viral agents in the development of the disease after the introduction of rotavirus vaccine immunization.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 4%
Unknown 49 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 16%
Student > Master 7 14%
Student > Doctoral Student 6 12%
Researcher 5 10%
Student > Postgraduate 5 10%
Other 7 14%
Unknown 13 25%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 18%
Biochemistry, Genetics and Molecular Biology 7 14%
Medicine and Dentistry 5 10%
Nursing and Health Professions 4 8%
Immunology and Microbiology 3 6%
Other 9 18%
Unknown 14 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 February 2016.
All research outputs
#10,978,486
of 12,355,257 outputs
Outputs from Brazilian Journal of Microbiology
#285
of 363 outputs
Outputs of similar age
#234,091
of 279,245 outputs
Outputs of similar age from Brazilian Journal of Microbiology
#7
of 8 outputs
Altmetric has tracked 12,355,257 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 363 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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