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Protein dynamics and conformational selection in bidirectional signal transduction

Overview of attention for article published in BMC Biology, January 2012
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

blogs
1 blog
twitter
4 tweeters
wikipedia
1 Wikipedia page

Citations

dimensions_citation
46 Dimensions

Readers on

mendeley
58 Mendeley
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Title
Protein dynamics and conformational selection in bidirectional signal transduction
Published in
BMC Biology, January 2012
DOI 10.1186/1741-7007-10-2
Pubmed ID
Authors

Ruth Nussinov, Buyong Ma

Abstract

Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways. The heterogeneous ensemble and loop dynamics explain how the EphA4 receptor is able to bind multiple A- and B-ephrin ligands and small molecules via conformational selection, which helps to fine-tune cellular signal response in both receptor and ligand cells.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
Israel 1 2%
Australia 1 2%
Chile 1 2%
Turkey 1 2%
Singapore 1 2%
Argentina 1 2%
United States 1 2%
Unknown 49 84%

Demographic breakdown

Readers by professional status Count As %
Researcher 14 24%
Student > Ph. D. Student 12 21%
Student > Master 7 12%
Professor > Associate Professor 6 10%
Student > Bachelor 4 7%
Other 12 21%
Unknown 3 5%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 41%
Biochemistry, Genetics and Molecular Biology 8 14%
Chemistry 8 14%
Physics and Astronomy 3 5%
Computer Science 3 5%
Other 7 12%
Unknown 5 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 April 2015.
All research outputs
#1,529,988
of 15,917,147 outputs
Outputs from BMC Biology
#475
of 1,363 outputs
Outputs of similar age
#17,528
of 219,720 outputs
Outputs of similar age from BMC Biology
#14
of 36 outputs
Altmetric has tracked 15,917,147 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,363 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 219,720 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.