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Mendeley readers
Attention Score in Context
| Title |
Class I Histone Deacetylase Inhibitor Entinostat Suppresses Regulatory T Cells and Enhances Immunotherapies in Renal and Prostate Cancer Models
|
|---|---|
| Published in |
PLOS ONE, January 2012
|
| DOI | 10.1371/journal.pone.0030815 |
| Pubmed ID | |
| Authors |
Li Shen, Michael Ciesielski, Swathi Ramakrishnan, Kiersten M. Miles, Leigh Ellis, Paula Sotomayor, Protul Shrikant, Robert Fenstermaker, Roberto Pili |
| Abstract |
Immunosuppressive factors such as regulatory T cells (Tregs) limit the efficacy of immunotherapies. Histone deacetylase (HDAC) inhibitors have been reported to have antitumor activity in different malignancies and immunomodulatory effects. Herein, we report the Tregs-targeting and immune-promoting effect of a class I specific HDAC inhibitor, entinostat, in combination with either IL-2 in a murine renal cell carcinoma (RENCA) model or a survivin-based vaccine therapy (SurVaxM) in a castration resistant prostate cancer (CR Myc-CaP) model. |
Mendeley readers
The data shown below were compiled from readership statistics for 145 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| Austria | 1 | <1% |
| France | 1 | <1% |
| Japan | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 139 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 21% |
| Student > Ph. D. Student | 26 | 18% |
| Student > Master | 17 | 12% |
| Student > Bachelor | 14 | 10% |
| Student > Doctoral Student | 9 | 6% |
| Other | 19 | 13% |
| Unknown | 29 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 23% |
| Biochemistry, Genetics and Molecular Biology | 22 | 15% |
| Agricultural and Biological Sciences | 20 | 14% |
| Immunology and Microbiology | 11 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 6% |
| Other | 13 | 9% |
| Unknown | 36 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 22. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2019.
All research outputs
#1,416,583
of 22,662,201 outputs
Outputs from PLOS ONE
#18,578
of 193,504 outputs
Outputs of similar age
#10,652
of 246,347 outputs
Outputs of similar age from PLOS ONE
#233
of 3,385 outputs
Altmetric has tracked 22,662,201 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 193,504 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.0. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 246,347 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 3,385 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.