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Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

Overview of attention for article published in Nature Genetics, January 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

news
1 news outlet
blogs
3 blogs
twitter
12 tweeters
patent
6 patents
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
859 Dimensions

Readers on

mendeley
585 Mendeley
citeulike
8 CiteULike
Title
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
Published in
Nature Genetics, January 2012
DOI 10.1038/ng.1102
Pubmed ID
Abstract

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 585 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 <1%
Canada 2 <1%
Spain 2 <1%
Netherlands 2 <1%
France 2 <1%
United Kingdom 2 <1%
Czechia 1 <1%
Sweden 1 <1%
Australia 1 <1%
Other 9 2%
Unknown 558 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 144 25%
Researcher 117 20%
Student > Bachelor 65 11%
Student > Master 59 10%
Other 41 7%
Other 114 19%
Unknown 45 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 195 33%
Medicine and Dentistry 132 23%
Biochemistry, Genetics and Molecular Biology 126 22%
Neuroscience 25 4%
Chemistry 14 2%
Other 38 6%
Unknown 55 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2020.
All research outputs
#425,243
of 14,931,539 outputs
Outputs from Nature Genetics
#1,013
of 6,379 outputs
Outputs of similar age
#3,900
of 215,989 outputs
Outputs of similar age from Nature Genetics
#7
of 86 outputs
Altmetric has tracked 14,931,539 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,379 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 215,989 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.