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Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

Overview of attention for article published in Nature Genetics, January 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
1 news outlet
blogs
3 blogs
twitter
12 tweeters
patent
4 patents
facebook
1 Facebook page
wikipedia
1 Wikipedia page

Citations

dimensions_citation
828 Dimensions

Readers on

mendeley
560 Mendeley
citeulike
8 CiteULike
Title
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas
Published in
Nature Genetics, January 2012
DOI 10.1038/ng.1102
Pubmed ID
Abstract

To identify somatic mutations in pediatric diffuse intrinsic pontine glioma (DIPG), we performed whole-genome sequencing of DNA from seven DIPGs and matched germline tissue and targeted sequencing of an additional 43 DIPGs and 36 non-brainstem pediatric glioblastomas (non-BS-PGs). We found that 78% of DIPGs and 22% of non-BS-PGs contained a mutation in H3F3A, encoding histone H3.3, or in the related HIST1H3B, encoding histone H3.1, that caused a p.Lys27Met amino acid substitution in each protein. An additional 14% of non-BS-PGs had somatic mutations in H3F3A causing a p.Gly34Arg alteration.

Twitter Demographics

The data shown below were collected from the profiles of 12 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 560 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 5 <1%
Canada 2 <1%
Spain 2 <1%
Netherlands 2 <1%
France 2 <1%
United Kingdom 2 <1%
Czechia 1 <1%
Sweden 1 <1%
Australia 1 <1%
Other 9 2%
Unknown 533 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 139 25%
Researcher 113 20%
Student > Bachelor 63 11%
Student > Master 53 9%
Other 41 7%
Other 110 20%
Unknown 41 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 194 35%
Medicine and Dentistry 131 23%
Biochemistry, Genetics and Molecular Biology 115 21%
Neuroscience 22 4%
Chemistry 13 2%
Other 35 6%
Unknown 50 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 45. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2018.
All research outputs
#375,141
of 13,333,056 outputs
Outputs from Nature Genetics
#965
of 6,188 outputs
Outputs of similar age
#3,853
of 210,231 outputs
Outputs of similar age from Nature Genetics
#8
of 86 outputs
Altmetric has tracked 13,333,056 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,188 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 31.7. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 210,231 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 86 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.