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Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

Overview of attention for article published in PLOS ONE, February 2012
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
4 news outlets
blogs
2 blogs
twitter
39 X users
patent
5 patents
peer_reviews
1 peer review site
wikipedia
3 Wikipedia pages
googleplus
1 Google+ user
f1000
1 research highlight platform

Citations

dimensions_citation
2106 Dimensions

Readers on

mendeley
1274 Mendeley
citeulike
10 CiteULike
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Title
Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
Published in
PLOS ONE, February 2012
DOI 10.1371/journal.pone.0030733
Pubmed ID
Authors

Julia Salzman, Charles Gawad, Peter Lincoln Wang, Norman Lacayo, Patrick O. Brown

Abstract

Most human pre-mRNAs are spliced into linear molecules that retain the exon order defined by the genomic sequence. By deep sequencing of RNA from a variety of normal and malignant human cells, we found RNA transcripts from many human genes in which the exons were arranged in a non-canonical order. Statistical estimates and biochemical assays provided strong evidence that a substantial fraction of the spliced transcripts from hundreds of genes are circular RNAs. Our results suggest that a non-canonical mode of RNA splicing, resulting in a circular RNA isoform, is a general feature of the gene expression program in human cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 1,274 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 24 2%
United Kingdom 6 <1%
Japan 6 <1%
Germany 5 <1%
Brazil 5 <1%
France 2 <1%
Italy 2 <1%
Luxembourg 2 <1%
China 2 <1%
Other 12 <1%
Unknown 1208 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 296 23%
Researcher 236 19%
Student > Master 156 12%
Student > Bachelor 142 11%
Student > Doctoral Student 62 5%
Other 170 13%
Unknown 212 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 451 35%
Biochemistry, Genetics and Molecular Biology 366 29%
Medicine and Dentistry 84 7%
Neuroscience 36 3%
Computer Science 23 2%
Other 82 6%
Unknown 232 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 76. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2023.
All research outputs
#559,425
of 25,359,594 outputs
Outputs from PLOS ONE
#7,672
of 220,057 outputs
Outputs of similar age
#3,193
of 259,561 outputs
Outputs of similar age from PLOS ONE
#83
of 3,358 outputs
Altmetric has tracked 25,359,594 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 220,057 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 259,561 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 3,358 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.