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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Sequential Signaling Crosstalk Regulates Endomesoderm Segregation in Sea Urchin Embryos
|
|---|---|
| Published in |
Science, February 2012
|
| DOI | 10.1126/science.1212867 |
| Pubmed ID | |
| Authors |
Aditya J. Sethi, Radhika M. Wikramanayake, Robert C. Angerer, Ryan C. Range, Lynne M. Angerer |
| Abstract |
The segregation of embryonic endomesoderm into separate endoderm and mesoderm fates is not well understood in deuterostomes. Using sea urchin embryos, we showed that Notch signaling initiates segregation of the endomesoderm precursor field by inhibiting expression of a key endoderm transcription factor in presumptive mesoderm. The regulatory circuit activated by this transcription factor subsequently maintains transcription of a canonical Wnt (cWnt) ligand only in endoderm precursors. This cWnt ligand reinforces the endoderm state, amplifying the distinction between emerging endoderm and mesoderm. Before gastrulation, Notch-dependent nuclear export of an essential β-catenin transcriptional coactivator from mesoderm renders it refractory to cWnt signals, insulating it against an endoderm fate. Thus, we report that endomesoderm segregation is a progressive process, requiring a succession of regulatory interactions between cWnt and Notch signaling. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 25% |
| Singapore | 1 | 25% |
| United States | 1 | 25% |
| Unknown | 1 | 25% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 93 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 5% |
| United Kingdom | 2 | 2% |
| Portugal | 1 | 1% |
| Japan | 1 | 1% |
| China | 1 | 1% |
| Unknown | 83 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 29 | 31% |
| Student > Ph. D. Student | 17 | 18% |
| Professor > Associate Professor | 7 | 8% |
| Student > Master | 5 | 5% |
| Student > Bachelor | 4 | 4% |
| Other | 8 | 9% |
| Unknown | 23 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 42 | 45% |
| Biochemistry, Genetics and Molecular Biology | 13 | 14% |
| Environmental Science | 3 | 3% |
| Unspecified | 2 | 2% |
| Computer Science | 2 | 2% |
| Other | 7 | 8% |
| Unknown | 24 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2016.
All research outputs
#7,251,105
of 24,208,207 outputs
Outputs from Science
#47,503
of 79,470 outputs
Outputs of similar age
#65,908
of 254,900 outputs
Outputs of similar age from Science
#433
of 745 outputs
Altmetric has tracked 24,208,207 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 79,470 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 64.2. This one is in the 40th percentile – i.e., 40% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 254,900 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 745 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.