Title |
Cytoadherence and virulence - the case of Plasmodium knowlesi malaria
|
---|---|
Published in |
Malaria Journal, February 2012
|
DOI | 10.1186/1475-2875-11-33 |
Pubmed ID | |
Authors |
Farrah A Fatih, Angela Siner, Atique Ahmed, Lu Chan Woon, Alister G Craig, Balbir Singh, Sanjeev Krishna, Janet Cox-Singh |
Abstract |
Cytoadherence of infected red blood cells to brain endothelium is causally implicated in malarial coma, one of the severe manifestations of falciparum malaria. Cytoadherence is mediated by specific binding of variant parasite antigens, expressed on the surface of infected erythrocytes, to endothelial receptors including, ICAM-1, VCAM and CD36. In fatal cases of severe falciparum malaria with coma, blood vessels in the brain are characteristically congested with infected erythrocytes. Brain sections from a fatal case of knowlesi malaria, but without coma, were similarly congested with infected erythrocytes. The objective of this study was to determine the binding phenotype of Plasmodium knowlesi infected human erythrocytes to recombinant human ICAM-1, VCAM and CD36. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Brazil | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Brazil | 2 | 2% |
Germany | 1 | 1% |
Kenya | 1 | 1% |
Indonesia | 1 | 1% |
Belgium | 1 | 1% |
United States | 1 | 1% |
Unknown | 87 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 15 | 16% |
Researcher | 15 | 16% |
Student > Bachelor | 11 | 12% |
Student > Master | 10 | 11% |
Student > Doctoral Student | 5 | 5% |
Other | 17 | 18% |
Unknown | 21 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 30 | 32% |
Medicine and Dentistry | 18 | 19% |
Biochemistry, Genetics and Molecular Biology | 13 | 14% |
Immunology and Microbiology | 5 | 5% |
Computer Science | 2 | 2% |
Other | 3 | 3% |
Unknown | 23 | 24% |