Title |
Tolerability and efficacy of the intestinal phosphate binder Lantharenol® in cats
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Published in |
BMC Veterinary Research, February 2012
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DOI | 10.1186/1746-6148-8-14 |
Pubmed ID | |
Authors |
Bernard H Schmidt, Ute Dribusch, Peet C Delport, Jürgen M Gropp, F Josef van der Staay |
Abstract |
Tolerability and efficacy of the intestinal phosphate binder Lantharenol® (lanthanum carbonate octahydrate) were tested in two prospective, randomized and negative controlled laboratory studies with healthy adult cats fed commercial maintenance diets non-restricted in phosphorus. In the first study, the maximal tolerated dose was determined. Starting from a dose of 0.125 g/kg body weight mixed with the daily feed ration, the dose of Lantharenol® was doubled every other week until signs of intolerability were observed (N=10 cats compared to 5 untreated controls). In the second study, the effects of feed supplementation for two weeks with approximately 2, 6, and 20% of the maximal tolerated dose on phosphorus excretion patterns and balance were assessed (N=8 cats per group). |
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