↓ Skip to main content

Reprogramming the assembly of unmodified DNA with a small molecule

Overview of attention for article published in Nature Chemistry, February 2016
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (96th percentile)

Mentioned by

news
14 news outlets
blogs
2 blogs
twitter
40 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
34 Dimensions

Readers on

mendeley
104 Mendeley
Title
Reprogramming the assembly of unmodified DNA with a small molecule
Published in
Nature Chemistry, February 2016
DOI 10.1038/nchem.2451
Pubmed ID
Authors

Nicole Avakyan, Andrea A. Greschner, Faisal Aldaye, Christopher J. Serpell, Violeta Toader, Anne Petitjean, Hanadi F. Sleiman

Abstract

The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA 'alphabet' by synthetic incorporation of new bases can introduce new functionalities and enable the formation of novel nucleic acid structures. However, reprogramming the self-assembly of existing nucleobases presents an alternative route to expand the structural space and functionality of nucleic acids. Here we report the discovery that a small molecule, cyanuric acid, with three thymine-like faces, reprogrammes the assembly of unmodified poly(adenine) (poly(A)) into stable, long and abundant fibres with a unique internal structure. Poly(A) DNA, RNA and peptide nucleic acid (PNA) all form these assemblies. Our studies are consistent with the association of adenine and cyanuric acid units into a hexameric rosette, which brings together poly(A) triplexes with a subsequent cooperative polymerization. Fundamentally, this study shows that small hydrogen-bonding molecules can be used to induce the assembly of nucleic acids in water, which leads to new structures from inexpensive and readily available materials.

Twitter Demographics

The data shown below were collected from the profiles of 40 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
United States 1 <1%
Hungary 1 <1%
Unknown 101 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 39%
Researcher 14 13%
Student > Doctoral Student 11 11%
Student > Master 11 11%
Student > Bachelor 9 9%
Other 18 17%
Readers by discipline Count As %
Chemistry 58 56%
Biochemistry, Genetics and Molecular Biology 10 10%
Materials Science 9 9%
Engineering 7 7%
Agricultural and Biological Sciences 7 7%
Other 13 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 139. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2018.
All research outputs
#97,278
of 12,902,279 outputs
Outputs from Nature Chemistry
#59
of 2,147 outputs
Outputs of similar age
#3,711
of 266,488 outputs
Outputs of similar age from Nature Chemistry
#2
of 58 outputs
Altmetric has tracked 12,902,279 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,147 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,488 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.