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Reprogramming the assembly of unmodified DNA with a small molecule

Overview of attention for article published in Nature Chemistry, February 2016
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (94th percentile)

Mentioned by

news
14 news outlets
blogs
2 blogs
twitter
38 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
110 Mendeley
Title
Reprogramming the assembly of unmodified DNA with a small molecule
Published in
Nature Chemistry, February 2016
DOI 10.1038/nchem.2451
Pubmed ID
Authors

Nicole Avakyan, Andrea A. Greschner, Faisal Aldaye, Christopher J. Serpell, Violeta Toader, Anne Petitjean, Hanadi F. Sleiman

Abstract

The ability of DNA to store and encode information arises from base pairing of the four-letter nucleobase code to form a double helix. Expanding this DNA 'alphabet' by synthetic incorporation of new bases can introduce new functionalities and enable the formation of novel nucleic acid structures. However, reprogramming the self-assembly of existing nucleobases presents an alternative route to expand the structural space and functionality of nucleic acids. Here we report the discovery that a small molecule, cyanuric acid, with three thymine-like faces, reprogrammes the assembly of unmodified poly(adenine) (poly(A)) into stable, long and abundant fibres with a unique internal structure. Poly(A) DNA, RNA and peptide nucleic acid (PNA) all form these assemblies. Our studies are consistent with the association of adenine and cyanuric acid units into a hexameric rosette, which brings together poly(A) triplexes with a subsequent cooperative polymerization. Fundamentally, this study shows that small hydrogen-bonding molecules can be used to induce the assembly of nucleic acids in water, which leads to new structures from inexpensive and readily available materials.

Twitter Demographics

The data shown below were collected from the profiles of 38 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Mexico 1 <1%
Hungary 1 <1%
United States 1 <1%
Unknown 107 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 41 37%
Researcher 14 13%
Student > Master 13 12%
Student > Doctoral Student 12 11%
Student > Bachelor 10 9%
Other 17 15%
Unknown 3 3%
Readers by discipline Count As %
Chemistry 60 55%
Biochemistry, Genetics and Molecular Biology 12 11%
Materials Science 8 7%
Agricultural and Biological Sciences 7 6%
Engineering 7 6%
Other 10 9%
Unknown 6 5%

Attention Score in Context

This research output has an Altmetric Attention Score of 138. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 May 2018.
All research outputs
#115,357
of 14,072,119 outputs
Outputs from Nature Chemistry
#70
of 2,280 outputs
Outputs of similar age
#3,887
of 267,186 outputs
Outputs of similar age from Nature Chemistry
#3
of 58 outputs
Altmetric has tracked 14,072,119 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,280 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 30.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,186 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 94% of its contemporaries.