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Analysis of host genetic diversity and viral entry as sources of between-host variation in viral load

Overview of attention for article published in Virus Research, April 2012
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Title
Analysis of host genetic diversity and viral entry as sources of between-host variation in viral load
Published in
Virus Research, April 2012
DOI 10.1016/j.virusres.2012.01.010
Pubmed ID
Authors

Andrew R. Wargo, Alison M. Kell, Robert J. Scott, Gary H. Thorgaard, Gael Kurath

Abstract

Little is known about the factors that drive the high levels of between-host variation in pathogen burden that are frequently observed in viral infections. Here, two factors thought to impact viral load variability, host genetic diversity and stochastic processes linked with viral entry into the host, were examined. This work was conducted with the aquatic vertebrate virus, Infectious hematopoietic necrosis virus (IHNV), in its natural host, rainbow trout. It was found that in controlled in vivo infections of IHNV, a suggestive trend of reduced between-fish viral load variation was observed in a clonal population of isogenic trout compared to a genetically diverse population of out-bred trout. However, this trend was not statistically significant for any of the four viral genotypes examined, and high levels of fish-to-fish variation persisted even in the isogenic trout population. A decrease in fish-to-fish viral load variation was also observed in virus injection challenges that bypassed the host entry step, compared to fish exposed to the virus through the natural water-borne immersion route of infection. This trend was significant for three of the four virus genotypes examined and suggests host entry may play a role in viral load variability. However, high levels of viral load variation also remained in the injection challenges. Together, these results indicate that although host genetic diversity and viral entry may play some role in between-fish viral load variation, they are not major factors. Other biological and non-biological parameters that may influence viral load variation are discussed.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Colombia 2 6%
Portugal 2 6%
Norway 1 3%
Canada 1 3%
Unknown 25 81%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 42%
Student > Master 4 13%
Student > Postgraduate 3 10%
Researcher 3 10%
Other 2 6%
Other 5 16%
Unknown 1 3%
Readers by discipline Count As %
Agricultural and Biological Sciences 18 58%
Biochemistry, Genetics and Molecular Biology 2 6%
Immunology and Microbiology 2 6%
Business, Management and Accounting 1 3%
Linguistics 1 3%
Other 3 10%
Unknown 4 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 February 2012.
All research outputs
#9,800,112
of 12,266,935 outputs
Outputs from Virus Research
#1,476
of 1,998 outputs
Outputs of similar age
#168,448
of 242,816 outputs
Outputs of similar age from Virus Research
#26
of 34 outputs
Altmetric has tracked 12,266,935 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,998 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 16th percentile – i.e., 16% of its peers scored the same or lower than it.
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We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 2nd percentile – i.e., 2% of its contemporaries scored the same or lower than it.