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Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection

Overview of attention for article published in Cytokine, June 2016
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (68th percentile)
  • High Attention Score compared to outputs of the same age and source (88th percentile)

Mentioned by

twitter
1 tweeter
wikipedia
1 Wikipedia page

Citations

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22 Dimensions

Readers on

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27 Mendeley
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Title
Imbalanced production of IL-18 and its antagonist in human diseases, and its implications for HIV-1 infection
Published in
Cytokine, June 2016
DOI 10.1016/j.cyto.2016.01.006
Pubmed ID
Authors

Suzanne Samarani, Ossama Allam, Patrick Sagala, Zainab Aldabah, Mohammad-Ali Jenabian, Vikram Mehraj, Cécile Tremblay, Jean-Pierre Routy, Devendra Amre, Ali Ahmad

Abstract

IL-18 is a pleiotropic and multifunctional cytokine that belongs to the IL-1 family. It is produced as a biologically inactive precursor, which is cleaved into its active mature form mainly by caspase-1. The caspase becomes active from its inactive precursor (procaspase-1) upon assembly of an inflammasome. Because of IL-18's potential pro-inflammatory and tissue destructive effects, its biological activities are tightly controlled in the body by its naturally occurring antagonist called IL-18BP. The antagonist is produced in the body both constitutively and in response to an increased production of IL-18 as a negative feedback mechanism. Under physiological conditions, most of IL-18 in the circulation is bound with IL-18BP and is inactive. However, an imbalance in the production of IL-18 and its antagonist (an increase in the production of IL-18 with a decrease, no increase or an insufficient increase in the production of IL-18BP) has been described in many chronic inflammatory diseases in humans. The imbalance results in an increase in the concentrations of free IL-18 (unbound with its antagonist) resulting in increased biological activities of the cytokine that contribute towards pathogenesis of the disease. In this article, we provide an overview of the current biology of IL-18 and its antagonist, discuss how the imbalance occurs in HIV infections and how it contributes towards development of AIDS and other non-AIDS-associated clinical conditions occurring in HIV-infected individuals undergoing combination anti-retroviral therapy (cART). Finally, we discuss challenges facing immunotherapeutic strategies aimed at restoring balance between IL-18 and its antagonist in these patients.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 27 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 6 22%
Student > Bachelor 5 19%
Student > Master 4 15%
Researcher 3 11%
Student > Postgraduate 2 7%
Other 4 15%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 9 33%
Agricultural and Biological Sciences 4 15%
Biochemistry, Genetics and Molecular Biology 3 11%
Immunology and Microbiology 3 11%
Veterinary Science and Veterinary Medicine 1 4%
Other 3 11%
Unknown 4 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2017.
All research outputs
#3,408,853
of 12,299,992 outputs
Outputs from Cytokine
#286
of 1,753 outputs
Outputs of similar age
#88,132
of 286,776 outputs
Outputs of similar age from Cytokine
#2
of 26 outputs
Altmetric has tracked 12,299,992 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 1,753 research outputs from this source. They receive a mean Attention Score of 2.8. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 286,776 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 88% of its contemporaries.