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Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis

Overview of attention for article published in Journal of Neuroinflammation, February 2016
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  • Good Attention Score compared to outputs of the same age (67th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (54th percentile)

Mentioned by

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7 tweeters

Readers on

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65 Mendeley
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Title
Sustained TNF production by central nervous system infiltrating macrophages promotes progressive autoimmune encephalomyelitis
Published in
Journal of Neuroinflammation, February 2016
DOI 10.1186/s12974-016-0513-y
Pubmed ID
Authors

Alice Valentin-Torres, Carine Savarin, David R. Hinton, Timothy W. Phares, Cornelia C. Bergmann, Stephen A. Stohlman

Abstract

Tumor necrosis factor (TNF) has pleiotropic functions during both the demyelinating autoimmune disease multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). How TNF regulates disability during progressive disease remains unresolved. Using a progressive EAE model characterized by sustained TNF and increasing morbidity, this study evaluates the role of unregulated TNF in exacerbating central nervous system (CNS) pathology and inflammation. Progressive MS was mimicked by myelin oligodendrocyte glycoprotein (MOG) peptide immunization of mice expressing a dominant negative IFN-γ receptor alpha chain under the human glial fibrillary acidic protein promoter (GFAPγR1∆). Diseased GFAPγR1∆ mice were treated with anti-TNF or control monoclonal antibody during acute disease to monitor therapeutic effects on sustained disability, demyelination, CNS inflammation, and blood brain barrier (BBB) permeability. TNF was specifically sustained in infiltrating macrophages. Anti-TNF treatment decreased established clinical disability and mortality rate within 7 days. Control of disease progression was associated with a decline in myelin loss and leukocyte infiltration, as well as macrophage activation. In addition to mitigating CNS inflammation, TNF neutralization restored BBB integrity and enhanced CNS anti-inflammatory responses. Sustained TNF production by infiltrating macrophages associated with progressive EAE exacerbates disease severity by promoting inflammation and disruption of BBB integrity, thereby counteracting establishment of an anti-inflammatory environment required for disease remission.

Twitter Demographics

The data shown below were collected from the profiles of 7 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 2%
Argentina 1 2%
Unknown 63 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 18%
Student > Ph. D. Student 10 15%
Student > Doctoral Student 9 14%
Student > Master 8 12%
Student > Postgraduate 6 9%
Other 13 20%
Unknown 7 11%
Readers by discipline Count As %
Medicine and Dentistry 14 22%
Biochemistry, Genetics and Molecular Biology 11 17%
Neuroscience 10 15%
Agricultural and Biological Sciences 9 14%
Immunology and Microbiology 8 12%
Other 3 5%
Unknown 10 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 June 2016.
All research outputs
#2,591,707
of 9,722,866 outputs
Outputs from Journal of Neuroinflammation
#370
of 1,238 outputs
Outputs of similar age
#92,723
of 291,739 outputs
Outputs of similar age from Journal of Neuroinflammation
#23
of 51 outputs
Altmetric has tracked 9,722,866 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 1,238 research outputs from this source. They receive a mean Attention Score of 4.8. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 291,739 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.