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Classification of different degrees of adiposity in sedentary rats

Overview of attention for article published in Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], January 2016
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Title
Classification of different degrees of adiposity in sedentary rats
Published in
Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], January 2016
DOI 10.1590/1414-431x20155028
Pubmed ID
Authors

Leopoldo, A S, Lima-Leopoldo, A P, Nascimento, A F, Luvizotto, R A M, Sugizaki, M M, Campos, D H S, da Silva, D C T, Padovani, C R, Cicogna, A C

Abstract

In experimental studies, several parameters, such as body weight, body mass index, adiposity index, and dual-energy X-ray absorptiometry, have commonly been used to demonstrate increased adiposity and investigate the mechanisms underlying obesity and sedentary lifestyles. However, these investigations have not classified the degree of adiposity nor defined adiposity categories for rats, such as normal, overweight, and obese. The aim of the study was to characterize the degree of adiposity in rats fed a high-fat diet using cluster analysis and to create adiposity intervals in an experimental model of obesity. Thirty-day-old male Wistar rats were fed a normal (n=41) or a high-fat (n=43) diet for 15 weeks. Obesity was defined based on the adiposity index; and the degree of adiposity was evaluated using cluster analysis. Cluster analysis allowed the rats to be classified into two groups (overweight and obese). The obese group displayed significantly higher total body fat and a higher adiposity index compared with those of the overweight group. No differences in systolic blood pressure or nonesterified fatty acid, glucose, total cholesterol, or triglyceride levels were observed between the obese and overweight groups. The adiposity index of the obese group was positively correlated with final body weight, total body fat, and leptin levels. Despite the classification of sedentary rats into overweight and obese groups, it was not possible to identify differences in the comorbidities between the two groups.

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Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 16 22%
Student > Bachelor 11 15%
Student > Ph. D. Student 10 14%
Student > Doctoral Student 7 9%
Student > Postgraduate 5 7%
Other 10 14%
Unknown 15 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 19%
Medicine and Dentistry 10 14%
Agricultural and Biological Sciences 8 11%
Nursing and Health Professions 5 7%
Neuroscience 4 5%
Other 16 22%
Unknown 17 23%